MetaCyc Pathway: valproate β-oxidation in Pseudomonas fluorescens FW300-N2C3

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Reactions and Genes L-Lysine (C)
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Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
AO356_26355 -0.1
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
AO356_02330 N.D.
AO356_04640 +0.0
AO356_10120 +0.0
AO356_12440 +0.0
AO356_17825 -0.4
AO356_20400 +0.1
AO356_20420 N.D.
AO356_25890 -0.2
AO356_26360 -0.9
AO356_26370 +0.2
AO356_26645 -0.4
AO356_27920 -0.1
AO356_30295 -0.1
AO356_30355 +0.2
AO356_30360 -0.1
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
AO356_02330 N.D.
AO356_10120 +0.0
AO356_13845 -0.1
AO356_20400 +0.1
AO356_30295 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
AO356_02325 -0.5
AO356_03560 -0.1
AO356_04930 -0.6
AO356_08090 +0.0
AO356_20395 +0.5
AO356_21640 -4.0
AO356_26350 -0.6
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
AO356_09020 -0.1
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
AO356_02330 N.D.
AO356_10120 +0.0
AO356_13845 -0.1
AO356_20400 +0.1
AO356_30295 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
AO356_02325 -0.5
AO356_03560 -0.1
AO356_04930 -0.6
AO356_08090 +0.0
AO356_20395 +0.5
AO356_21640 -4.0
AO356_26350 -0.6
AO356_30300 +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information