MetaCyc Pathway: serotonin degradation in Pseudomonas fluorescens FW300-N2C3

Add experiment(s):


Reactions and Genes L-Lysine (C)
remove
Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
AO356_13575 +0.1
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
AO356_00680 -0.1
AO356_07180 +0.1
AO356_08510 -1.7
AO356_09270 -0.2
AO356_12580 -0.4
AO356_13300 +0.0
AO356_15145 +0.1
AO356_15225 -0.5
AO356_25765 -0.0
AO356_26800 -0.4
AO356_27135 +0.6
AO356_27520 -0.5
AO356_28025 -1.9
AO356_28685 -0.8
AO356_28710 -0.1
AO356_29070 -0.0
AO356_30220 -0.0
AO356_30285 -0.5
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
AO356_00820 -0.1
AO356_04765 -0.0
AO356_05920 -0.3
AO356_14405 -0.2
AO356_20305 -0.1
AO356_28020 +0.2
AO356_29985 -0.5
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information