MetaCyc Pathway: superpathway of coenzyme A biosynthesis I (bacteria) in Bifidobacterium breve UCC2003

Add experiment(s):


Reactions and Genes CDM1 without Leucine
remove
3-methyl-2-oxobutanoate hydroxymethyltransferase:
3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H2O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)
No genes
Aspartate 1-decarboxylase:
L-aspartate + H+→β-alanine + CO2 (EC 4.1.1.11)
No genes
2-dehydropantoate 2-reductase (in reverse):
2-dehydropantoate + NADPH + H+→(R)-pantoate + NADP+ (EC 1.1.1.169)
BBR_RS10800 -0.4
BBR_RS10830 -1.1
Pantoate--beta-alanine ligase:
β-alanine + (R)-pantoate + ATP→(R)-pantothenate + AMP + diphosphate + H+ (EC 6.3.2.1)
No genes
Pantothenate kinase:
(R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H+ (EC 2.7.1.33)
BBR_RS13110 +0.6
Phosphopantothenate--cysteine ligase:
(R)-4'-phosphopantothenate + CTP + L-cysteine→(R)-4'-phosphopantothenoyl-L-cysteine + CMP + diphosphate + H+ (EC 6.3.2.5)
No genes
Phosphopantothenoylcysteine decarboxylase:
(R)-4'-phosphopantothenoyl-L-cysteine + H+→4'-phosphopantetheine + CO2 (EC 4.1.1.36)
No genes
Pantetheine-phosphate adenylyltransferase:
4'-phosphopantetheine + ATP + H+→3'-dephospho-CoA + diphosphate (EC 2.7.7.3)
BBR_RS12375 -1.3
Dephospho-CoA kinase:
3'-dephospho-CoA + ATP→coenzyme A + ADP + H+ (EC 2.7.1.24)
BBR_RS14280 -1.7

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information