MetaCyc Pathway: 2-methyl-branched fatty acid β-oxidation in Burkholderia phytofirmans PsJN

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Reactions and Genes Trisodium citrate (C)
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Butyrate--CoA ligase:
a short-chain 2-methyl-branched fatty acid + ATP + coenzyme A→a short-chain 2-methyl fatty acyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
a long-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a long-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Butyrate--CoA ligase:
a medium-chain 2-methyl-branched fatty acid + ATP + coenzyme A→a medium-chain 2-methyl fatty acyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
a short-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a short-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
a medium-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a medium-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
BPHYT_RS03220 -1.1
BPHYT_RS07100 -0.0
BPHYT_RS18740 -0.1
BPHYT_RS35460 +0.1
Enoyl-CoA hydratase (in reverse):
a long-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a long-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
BPHYT_RS02345 +0.3
BPHYT_RS03225 -0.2
BPHYT_RS03235 -0.5
BPHYT_RS03825 N.D.
BPHYT_RS06755 N.D.
BPHYT_RS06760 -0.0
BPHYT_RS08375 N.D.
BPHYT_RS08630 -0.2
BPHYT_RS09560 -0.1
BPHYT_RS10815 N.D.
BPHYT_RS11780 N.D.
BPHYT_RS13345 -0.3
BPHYT_RS13545 -0.0
BPHYT_RS14830 +0.2
BPHYT_RS17335 +0.2
BPHYT_RS17350 N.D.
BPHYT_RS20025 +0.1
BPHYT_RS25360 N.D.
BPHYT_RS25695 N.D.
BPHYT_RS27105 +0.2
BPHYT_RS27895 +0.0
BPHYT_RS28015 +0.0
BPHYT_RS28020 N.D.
BPHYT_RS28620 +0.0
BPHYT_RS35465 +0.3
Enoyl-CoA hydratase (in reverse):
a short-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a short-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
BPHYT_RS02345 +0.3
BPHYT_RS03225 -0.2
BPHYT_RS03235 -0.5
BPHYT_RS03825 N.D.
BPHYT_RS06755 N.D.
BPHYT_RS06760 -0.0
BPHYT_RS08375 N.D.
BPHYT_RS08630 -0.2
BPHYT_RS09560 -0.1
BPHYT_RS10815 N.D.
BPHYT_RS11780 N.D.
BPHYT_RS13345 -0.3
BPHYT_RS13545 -0.0
BPHYT_RS14830 +0.2
BPHYT_RS17335 +0.2
BPHYT_RS17350 N.D.
BPHYT_RS20025 +0.1
BPHYT_RS25360 N.D.
BPHYT_RS25695 N.D.
BPHYT_RS27105 +0.2
BPHYT_RS27895 +0.0
BPHYT_RS28015 +0.0
BPHYT_RS28020 N.D.
BPHYT_RS28620 +0.0
BPHYT_RS35465 +0.3
Enoyl-CoA hydratase (in reverse):
a medium-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a medium-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
BPHYT_RS02345 +0.3
BPHYT_RS03225 -0.2
BPHYT_RS03235 -0.5
BPHYT_RS03825 N.D.
BPHYT_RS06755 N.D.
BPHYT_RS06760 -0.0
BPHYT_RS08375 N.D.
BPHYT_RS08630 -0.2
BPHYT_RS09560 -0.1
BPHYT_RS10815 N.D.
BPHYT_RS11780 N.D.
BPHYT_RS13345 -0.3
BPHYT_RS13545 -0.0
BPHYT_RS14830 +0.2
BPHYT_RS17335 +0.2
BPHYT_RS17350 N.D.
BPHYT_RS20025 +0.1
BPHYT_RS25360 N.D.
BPHYT_RS25695 N.D.
BPHYT_RS27105 +0.2
BPHYT_RS27895 +0.0
BPHYT_RS28015 +0.0
BPHYT_RS28020 N.D.
BPHYT_RS28620 +0.0
BPHYT_RS35465 +0.3
3-hydroxyacyl-CoA dehydrogenase:
a long-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a long-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35)
BPHYT_RS03225 -0.2
BPHYT_RS06760 -0.0
BPHYT_RS09560 -0.1
BPHYT_RS13545 -0.0
BPHYT_RS34155 -0.1
3-hydroxy-2-methylbutyryl-CoA dehydrogenase:
a short-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a short-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.178)
No genes
3-hydroxyacyl-CoA dehydrogenase:
a medium-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a medium-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35)
BPHYT_RS03225 -0.2
BPHYT_RS06760 -0.0
BPHYT_RS09560 -0.1
BPHYT_RS13545 -0.0
BPHYT_RS34155 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
a long-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a long-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
BPHYT_RS02230 -0.3
BPHYT_RS03230 -0.4
BPHYT_RS08275 -0.1
BPHYT_RS09150 +0.2
BPHYT_RS09180 -0.1
BPHYT_RS09565 +0.4
BPHYT_RS17345 +0.1
BPHYT_RS21955 +0.1
BPHYT_RS29385 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
a short-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a short-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
BPHYT_RS02230 -0.3
BPHYT_RS03230 -0.4
BPHYT_RS08275 -0.1
BPHYT_RS09150 +0.2
BPHYT_RS09180 -0.1
BPHYT_RS09565 +0.4
BPHYT_RS17345 +0.1
BPHYT_RS21955 +0.1
BPHYT_RS29385 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
a medium-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a medium-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
BPHYT_RS02230 -0.3
BPHYT_RS03230 -0.4
BPHYT_RS08275 -0.1
BPHYT_RS09150 +0.2
BPHYT_RS09180 -0.1
BPHYT_RS09565 +0.4
BPHYT_RS17345 +0.1
BPHYT_RS21955 +0.1
BPHYT_RS29385 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information