MetaCyc Pathway: superpathway of aromatic amino acid biosynthesis in Sinorhizobium meliloti 1021

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Reactions and Genes LB, pH8
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
SMc00155 N.D.
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
SMc00696 N.D.
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
SMc01028 +0.4
SMc01343 N.D.
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
SM_b20037 +0.1
SMc02791 N.D.
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
SMc00695 N.D.
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
SMc00333 N.D.
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
SMc00007 N.D.
Anthranilate synthase:
chorismate + L-glutamine→anthranilate + L-glutamate + H+ + pyruvate (EC 4.1.3.27)
SMc02725 -0.1
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
SMc03858 N.D.
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
SMc02899 -0.2
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
SMc00711 +2.6
Anthranilate phosphoribosyltransferase (in reverse):
anthranilate + 5-phospho-α-D-ribose 1-diphosphate→N-(5-phosphoribosyl)-anthranilate + diphosphate (EC 2.4.2.18)
SMc00235 +0.5
Phosphoribosylanthranilate isomerase:
N-(5-phosphoribosyl)-anthranilate→1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (EC 5.3.1.24)
SMc02767 +0.7
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
SM_b20039 -0.0
SMa0387 +0.1
SMc00294 +0.3
SMc00387 -0.1
SMc00490 +0.3
SMc00710 +1.0
SMc01406 -0.4
SMc01578 +0.2
SMc01969 -1.5
SMc02251 +0.2
SMc02262 -0.1
SMc02393 +0.2
SMc03885 +0.1
SMc04323 +0.1
SMc04326 -0.2
SMc04386 -0.4
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
SM_b20039 -0.0
SMa0387 +0.1
SMc00294 +0.3
SMc00387 -0.1
SMc00490 +0.3
SMc00710 +1.0
SMc01406 -0.4
SMc01578 +0.2
SMc01969 -1.5
SMc02251 +0.2
SMc02262 -0.1
SMc02393 +0.2
SMc03885 +0.1
SMc04323 +0.1
SMc04326 -0.2
SMc04386 -0.4
Indole-3-glycerol-phosphate synthase:
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+→(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O (EC 4.1.1.48)
SMc00236 +0.4
Indole-3-glycerol-phosphate lyase:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate→indole + D-glyceraldehyde 3-phosphate (EC 4.1.2.8; 4.2.1.20)
SMc02765 +2.3
SMc02766 +2.3
indole + L-serine→L-tryptophan + H2O (EC 4.2.1.122; 4.2.1.20)
SMc02765 +2.3
SMc02766 +2.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information