MetaCyc Pathway: L-arginine biosynthesis II (acetyl cycle) in Sinorhizobium meliloti 1021

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Reactions and Genes LB, pH8
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Glutamate--ammonia ligase:
L-glutamate + ammonium + ATP→L-glutamine + ADP + H+ + phosphate (EC 6.3.1.2)
SM_b20745 +0.2
SMc00762 +0.1
SMc00948 -1.7
SMc01594 -0.0
SMc01973 +0.5
SMc02352 +0.2
SMc02613 +0.0
Amino-acid N-acetyltransferase:
L-glutamate + acetyl-CoA→N-acetyl-L-glutamate + coenzyme A + H+ (EC 2.3.1.1)
SMc01437 N.D.
SMc02450 +0.1
Acetylglutamate kinase:
N-acetyl-L-glutamate + ATP→N-acetylglutamyl-phosphate + ADP (EC 2.7.2.8)
SMc01726 -0.2
SMc03791 -0.1
Carbamoyl-phosphate synthase (glutamine-hydrolyzing):
L-glutamine + 2 ATP + hydrogen carbonate + H2O→L-glutamate + carbamoyl phosphate + 2 ADP + 2 H+ + phosphate (EC 6.3.5.5)
SM_b21227 +0.1
SMc01215 +1.1
SMc01569 -0.2
N-acetyl-gamma-glutamyl-phosphate reductase (in reverse):
N-acetylglutamyl-phosphate + NADPH + H+→N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.38)
SMc01801 +0.5
Ornithine carbamoyltransferase:
carbamoyl phosphate + L-ornithine→L-citrulline + H+ + phosphate (EC 2.1.3.3)
SMa0695 +0.1
SMc02137 +2.4
Acetylornithine transaminase (in reverse):
N-acetyl-L-glutamate 5-semialdehyde + L-glutamate→N-acetyl-L-ornithine + 2-oxoglutarate (EC 2.6.1.11)
SMc02138 +1.3
SMc02413 -0.2
Argininosuccinate synthase:
L-citrulline + ATP + L-aspartate→L-arginino-succinate + AMP + diphosphate + H+ (EC 6.3.4.5)
SMc03826 +1.5
Argininosuccinate lyase:
L-arginino-succinate→L-arginine + fumarate (EC 4.3.2.1)
SM_b21094 +0.1
SMc00725 +1.1
Glutamate N-acetyltransferase:
L-glutamate + N-acetyl-L-ornithine→N-acetyl-L-glutamate + L-ornithine (EC 2.3.1.35)
SMc02450 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information