MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Sinorhizobium meliloti 1021

Reactions and Genes	D-Cycloserine 0.05 mg/ml
3-deoxy-7-phosphoheptulonate synthase: D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
SMc00155	N.D.
3-dehydroquinate synthase: 3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
SMc00696	N.D.
3-dehydroquinate dehydratase: 3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
SMc01028	-0.1
SMc01343	N.D.
Shikimate dehydrogenase (in reverse): 3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
SM_b20037	-0.3
SMc02791	N.D.
Shikimate kinase: shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
SMc00695	N.D.
3-phosphoshikimate 1-carboxyvinyltransferase: shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
SMc00333	N.D.
Chorismate synthase: 5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
SMc00007	N.D.
Chorismate mutase: chorismate→prephenate (EC 5.4.99.5)
SMc03858	N.D.
Prephenate dehydrogenase: prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
SMc00711	+5.1
Aspartate transaminase (in reverse): 3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
SM_b20039	-2.2
SMa0387	+0.1
SMc00294	+0.1
SMc00387	+0.0
SMc00490	+0.1
SMc00710	+2.6
SMc01406	-0.2
SMc01578	-0.4
SMc01969	-0.7
SMc02251	-0.1
SMc02262	-0.0
SMc02393	-0.0
SMc03885	-0.1
SMc04323	+0.1
SMc04326	-0.1
SMc04386	-0.5

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information