MetaCyc Pathway: 4-hydroxybenzoate biosynthesis I (eukaryotes) in Sinorhizobium meliloti 1021

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Reactions and Genes A22 0.02 mg/ml
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Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
SM_b20039 +0.0
SMa0387 +0.1
SMc00294 +0.1
SMc00387 +0.1
SMc00490 +0.1
SMc00710 +0.2
SMc01406 -0.1
SMc01578 -0.1
SMc01969 -1.5
SMc02251 -0.1
SMc02262 -0.0
SMc02393 -0.0
SMc03885 +0.1
SMc04323 +0.1
SMc04326 -0.0
SMc04386 -0.6
Indolelactate dehydrogenase (in reverse):
3-(4-hydroxyphenyl)pyruvate + NADH + H+→(R)-3-(4-hydroxyphenyl)lactate + NAD+ (EC 1.1.1.110)
No genes
Cinnamoyl-CoA:phenyllactate CoA-transferase:
(R)-3-(4-hydroxyphenyl)lactate + (E)-4-coumaroyl-CoA→4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA (EC 2.8.3.17)
No genes
4-coumarate + H2O→4-hydroxybenzaldehyde + acetate
No genes
4-hydroxybenzaldehyde dehydrogenase:
4-hydroxybenzaldehyde + NAD+ + H2O→4-hydroxybenzoate + NADH + 2 H+ (EC 1.2.1.64)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information