MetaCyc Pathway: L-valine degradation I in Ralstonia sp. UNC404CL21Col

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Reactions and Genes Trans-2-methyl-2-butenoic (C)
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Branched-chain-amino-acid transaminase:
L-valine + 2-oxoglutarate→3-methyl-2-oxobutanoate + L-glutamate (EC 2.6.1.42)
ABZR87_RS18540 -0.3
2-oxoisovalerate dehydrogenase (acylating):
3-methyl-2-oxobutanoate + coenzyme A + NAD+→isobutanoyl-CoA + CO2 + NADH (EC 1.2.1.25)
No genes
isobutanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→methylacrylyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
methylacrylyl-CoA + H2O→(S)-3-hydroxy-isobutanoyl-CoA (EC 4.2.1.150)
ABZR87_RS06190 +0.2
ABZR87_RS06470 +0.0
ABZR87_RS07480 -0.1
ABZR87_RS07495 +0.1
ABZR87_RS11295 +0.0
ABZR87_RS12585 +0.0
ABZR87_RS14660 +0.1
ABZR87_RS16545 +0.0
ABZR87_RS16935 -0.1
ABZR87_RS17480 N.D.
ABZR87_RS20900 +0.5
ABZR87_RS21810 -0.3
3-hydroxyisobutyryl-CoA hydrolase:
(S)-3-hydroxy-isobutanoyl-CoA + H2O→(S)-3-hydroxy-isobutanoate + coenzyme A + H+ (EC 3.1.2.4)
ABZR87_RS17485 -0.4
3-hydroxyisobutyrate dehydrogenase:
(S)-3-hydroxy-isobutanoate + NAD+→(S)-methylmalonate-semialdehyde + NADH + H+ (EC 1.1.1.31)
ABZR87_RS05245 -0.0
ABZR87_RS07480 -0.1
ABZR87_RS12585 +0.0
ABZR87_RS14655 +0.0
ABZR87_RS17475 -1.7
ABZR87_RS23345 -0.3
(S)-3-amino-2-methylpropionate transaminase (in reverse):
(S)-methylmalonate-semialdehyde + L-glutamate→(S)-3-amino-2-methylpropanoate + 2-oxoglutarate (EC 2.6.1.22)
No genes
Methylmalonate-semialdehyde dehydrogenase (acylating):
(S)-methylmalonate-semialdehyde + coenzyme A + NAD+ + H2O→propanoyl-CoA + hydrogen carbonate + NADH + H+ (EC 1.2.1.27)
ABZR87_RS17470 -1.2
ABZR87_RS19665 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information