MetaCyc Pathway: colanic acid building blocks biosynthesis in Burkholderia phytofirmans PsJN

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Reactions and Genes Lomefloxacin 0.001 mM
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Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
BPHYT_RS09500 +1.0
Phosphoglucomutase (in reverse):
D-glucopyranose 6-phosphate→α-D-glucopyranose 1-phosphate (EC 5.4.2.2)
BPHYT_RS04470 N.D.
BPHYT_RS14155 N.D.
UTP-monosaccharide-1-phosphate uridylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + UTP→UDP-α-D-glucose + diphosphate (EC 2.7.7.64; 2.7.7.9)
BPHYT_RS09795 +0.1
BPHYT_RS13860 N.D.
BPHYT_RS31105 N.D.
Mannose-6-phosphate isomerase (in reverse):
β-D-fructofuranose 6-phosphate→D-mannopyranose 6-phosphate (EC 5.3.1.8)
BPHYT_RS03980 -0.1
BPHYT_RS04415 -0.2
BPHYT_RS08530 N.D.
BPHYT_RS09705 -0.3
BPHYT_RS11350 N.D.
BPHYT_RS13015 N.D.
BPHYT_RS29610 +0.1
BPHYT_RS31080 N.D.
BPHYT_RS34175 +1.2
BPHYT_RS34950 N.D.
Phosphomannomutase (in reverse):
D-mannopyranose 6-phosphate→α-D-mannose 1-phosphate (EC 5.4.2.8)
BPHYT_RS04470 N.D.
UDP-glucose 4-epimerase:
UDP-α-D-glucose→UDP-α-D-galactose (EC 5.1.3.2)
BPHYT_RS04260 +0.1
BPHYT_RS04375 N.D.
BPHYT_RS04450 +0.6
BPHYT_RS07405 -0.2
BPHYT_RS23350 -0.4
BPHYT_RS24115 -0.4
BPHYT_RS24165 +0.1
BPHYT_RS31050 +0.8
BPHYT_RS33225 +0.5
UDP-glucose 6-dehydrogenase:
UDP-α-D-glucose + 2 NAD+ + H2O→UDP-α-D-glucuronate + 2 NADH + 3 H+ (EC 1.1.1.22)
BPHYT_RS09715 +0.2
BPHYT_RS14865 -7.9
BPHYT_RS23345 +0.2
BPHYT_RS29845 N.D.
Mannose-1-phosphate guanylyltransferase:
α-D-mannose 1-phosphate + GTP + H+→GDP-α-D-mannose + diphosphate (EC 2.7.7.13)
BPHYT_RS31080 N.D.
GDP-mannose 4,6-dehydratase:
GDP-α-D-mannose→GDP-4-dehydro-α-D-rhamnose + H2O (EC 4.2.1.47)
BPHYT_RS04000 -0.1
BPHYT_RS09760 N.D.
GDP-L-fucose synthase:
GDP-4-dehydro-α-D-rhamnose→GDP-4-dehydro-6-deoxy-β-L-galactose (EC 1.1.1.271)
BPHYT_RS04005 -0.0
GDP-L-fucose synthase (in reverse):
GDP-4-dehydro-6-deoxy-β-L-galactose + NADPH + H+→GDP-β-L-fucose + NADP+ (EC 1.1.1.271)
BPHYT_RS04005 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information