MetaCyc Pathway: benzoate biosynthesis I (CoA-dependent, β-oxidative) in Ralstonia sp. UNC404CL21Col

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Reactions and Genes Trans-2-methyl-2-butenoic (C)
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Phenylalanine ammonia-lyase:
L-phenylalanine→trans-cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
No genes
trans-cinnamate + ATP + coenzyme A→(E)-cinnamoyl-CoA + AMP + diphosphate
No genes
Enoyl-CoA hydratase (in reverse):
(E)-cinnamoyl-CoA + H2O→(S)-3-hydroxy-3-phenylpropanoyl-CoA (EC 4.2.1.17)
ABZR87_RS02095 +0.2
ABZR87_RS02100 +0.2
ABZR87_RS06190 -0.3
ABZR87_RS06470 +0.1
ABZR87_RS07480 -0.1
ABZR87_RS07495 +0.3
ABZR87_RS11295 -0.1
ABZR87_RS12585 +0.2
ABZR87_RS14655 -0.0
ABZR87_RS14660 +0.1
ABZR87_RS16545 -0.1
ABZR87_RS16935 -0.2
ABZR87_RS17480 N.D.
ABZR87_RS17485 -0.2
ABZR87_RS20520 -0.0
ABZR87_RS20900 -0.0
ABZR87_RS21810 -0.0
ABZR87_RS23090 +0.1
ABZR87_RS23345 -0.2
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-3-phenylpropanoyl-CoA + NAD+→3-oxo-3-phenylpropanoyl-CoA + NADH + H+ (EC 1.1.1.35)
ABZR87_RS00745 -4.9
ABZR87_RS07480 -0.1
ABZR87_RS12585 +0.2
ABZR87_RS14655 -0.0
ABZR87_RS23345 -0.2
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-3-phenylpropanoyl-CoA + coenzyme A→benzoyl-CoA + acetyl-CoA (EC 2.3.1.16)
ABZR87_RS06305 -5.4
ABZR87_RS07485 -0.3
ABZR87_RS07810 -0.1
ABZR87_RS12575 -0.0
ABZR87_RS13270 +0.2
ABZR87_RS13295 -0.2
ABZR87_RS15790 +0.0
ABZR87_RS23340 -0.3
benzoyl-CoA + H2O→benzoate + coenzyme A + H+
No genes
benzoyl-CoA + benzyl alcohol→benzyl benzoate + coenzyme A (EC 2.3.1.196)
No genes
benzyl benzoate + H2O→benzoate + benzyl alcohol + H+
No genes
Benzoate--CoA ligase:
benzoate + ATP + coenzyme A→benzoyl-CoA + AMP + diphosphate (EC 6.2.1.25)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information