MetaCyc Pathway: superpathway of L-citrulline metabolism in Shewanella sp. ANA-3

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Reactions and Genes L-Proline (N)
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Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+ (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
Shewana3_0265 -0.1
Shewana3_0296 -0.2
Shewana3_0606 +0.3
Shewana3_0753 +0.1
Shewana3_0890 +0.5
Shewana3_0967 -3.7
Shewana3_0968 (carB) -4.1
Shewana3_0974 +0.1
Shewana3_1115 (pyrG) N.D.
Shewana3_1184 -0.0
Shewana3_1209 +0.0
Shewana3_1236 (guaA) -2.3
Shewana3_1311 -0.0
Shewana3_1519 -3.3
Shewana3_1520 -3.4
Shewana3_1696 +0.4
Shewana3_2303 -0.0
Shewana3_2549 (asnB) -5.0
Shewana3_2598 N.D.
Shewana3_2851 +0.1
Shewana3_3050 (gltB) -1.5
Shewana3_3051 (gltD) -1.5
Shewana3_3523 -0.1
Shewana3_3782 +0.1
Shewana3_3808 +0.2
Shewana3_3865 -0.1
Shewana3_3866 -0.0
Shewana3_3952 +1.0
Carbamoyl-phosphate synthase (ammonia):
ammonium + 2 ATP + hydrogen carbonate→carbamoyl phosphate + 2 ADP + 2 H+ + phosphate (EC 6.3.4.16)
No genes
L-proline[in] + an electron-transfer quinone→(S)-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.2)
Shewana3_0819 -3.2
Glutamate 5-kinase:
L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP (EC 2.7.2.11)
Shewana3_0954 +0.1
Shewana3_4056 +0.0
(S)-1-pyrroline-5-carboxylate + H+ + H2O→L-glutamate 5-semialdehyde (spontaneous)
No genes
Glutamate-5-semialdehyde dehydrogenase (in reverse):
γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.41)
Shewana3_0955 (proA) -0.1
Shewana3_4057 -0.2
Ornithine aminotransferase (in reverse):
L-glutamate + L-glutamate 5-semialdehyde→L-ornithine + 2-oxoglutarate (EC 2.6.1.13)
Shewana3_0610 (argD) -0.8
Ornithine carbamoyltransferase:
L-ornithine + carbamoyl phosphate→L-citrulline + H+ + phosphate (EC 2.1.3.3)
Shewana3_3903 -3.6
Argininosuccinate synthase:
L-citrulline + ATP + L-aspartate→L-arginino-succinate + AMP + diphosphate + H+ (EC 6.3.4.5)
Shewana3_3902 -4.3
Argininosuccinate lyase:
L-arginino-succinate→L-arginine + fumarate (EC 4.3.2.1)
Shewana3_3901 -3.9
Arginase:
L-arginine + H2O→L-ornithine + urea (EC 3.5.3.1)
No genes
Nitric-oxide synthase:
2 L-arginine + 3 NADPH + 4 dioxygen + H+→2 L-citrulline + 3 NADP+ + 2 nitric oxide + 4 H2O (EC 1.14.13.39)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information