MetaCyc Pathway: L-tyrosine degradation I in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes L-Phenylalanine (C)
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Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
Pf6N2E2_1496 +0.0
Pf6N2E2_2127 -0.1
Pf6N2E2_2446 -0.0
Pf6N2E2_2519 -0.2
Pf6N2E2_2632 -3.3
Pf6N2E2_3173 +0.1
Pf6N2E2_3251 -3.5
Pf6N2E2_4288 -0.2
Pf6N2E2_4386 +0.0
Pf6N2E2_462 +0.0
Pf6N2E2_50 +0.2
Pf6N2E2_5300 -0.2
Pf6N2E2_5813 +0.1
Pf6N2E2_5890 -0.1
Pf6N2E2_5891 N.D.
Pf6N2E2_5895 -0.1
Pf6N2E2_5989 -0.4
Pf6N2E2_637 +0.2
Pf6N2E2_684 +0.1
4-hydroxyphenylpyruvate dioxygenase:
3-(4-hydroxyphenyl)pyruvate + dioxygen→homogentisate + CO2 (EC 1.13.11.27)
Pf6N2E2_1001 -0.1
Pf6N2E2_456 -4.4
Pf6N2E2_5058 +0.3
Pf6N2E2_988 -0.1
Homogentisate 1,2-dioxygenase:
homogentisate + dioxygen→4-maleyl-acetoacetate + H+ (EC 1.13.11.5)
Pf6N2E2_5290 -4.2
Maleylacetoacetate isomerase:
4-maleyl-acetoacetate→4-fumaryl-acetoacetate (EC 5.2.1.2)
Pf6N2E2_5292 -4.2
Fumarylacetoacetase:
4-fumaryl-acetoacetate + H2O→acetoacetate + fumarate + H+ (EC 3.7.1.2)
Pf6N2E2_5291 -4.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information