MetaCyc Pathway: superpathway of L-threonine biosynthesis in Bifidobacterium breve UCC2003

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Reactions and Genes CDM1 without Pyridoxamine
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
BBR_RS13205 -5.7
BBR_RS13460 -0.2
BBR_RS14535 -0.1
BBR_RS15505 -1.6
BBR_RS15560 +0.8
BBR_RS17345 -0.1
BBR_RS17965 -0.2
BBR_RS19435 +0.4
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
BBR_RS11015 -6.5
BBR_RS11020 -6.1
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
BBR_RS11025 -6.4
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
BBR_RS19540 -2.5
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
BBR_RS19535 -5.8
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
BBR_RS14070 -4.8

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information