MetaCyc Pathway: superpathway of L-threonine biosynthesis in Azospirillum brasilense Sp245

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Reactions and Genes L-Leucine (N)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
AZOBR_RS06555 -2.3
AZOBR_RS07050 -0.1
AZOBR_RS07650 -0.3
AZOBR_RS07830 N.D.
AZOBR_RS12970 N.D.
AZOBR_RS16760 -0.2
AZOBR_RS20195 +0.1
AZOBR_RS22530 -0.2
AZOBR_RS24065 +0.0
AZOBR_RS27565 +0.2
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
AZOBR_RS18890 N.D.
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
AZOBR_RS13975 +0.2
AZOBR_RS14735 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
AZOBR_RS07835 N.D.
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
AZOBR_RS10500 N.D.
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
AZOBR_RS10545 N.D.
AZOBR_RS16025 -0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information