| Reactions and Genes | CDM1 without Methionine |
|---|
| remove |
Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1) |
| BBR_RS13205 | +0.0 |
| BBR_RS13460 | -0.2 |
| BBR_RS14535 | +0.5 |
| BBR_RS15505 | -0.3 |
| BBR_RS15560 | +0.7 |
| BBR_RS17345 | -0.1 |
| BBR_RS17965 | -0.3 |
| BBR_RS19435 | +1.4 |
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4) |
| BBR_RS11015 | -4.6 |
| BBR_RS11020 | -4.5 |
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11) |
| BBR_RS11025 | -4.7 |
| L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7) |
| BBR_RS11135 | +0.3 |
| BBR_RS12995 | -1.1 |
| BBR_RS17075 | +0.0 |
| BBR_RS19480 | +0.1 |
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3) |
| BBR_RS19540 | -2.5 |
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39) |
| BBR_RS19535 | -4.3 |
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A (EC 2.3.1.46) |
| BBR_RS11990 | -2.7 |
| (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8) |
| BBR_RS12990 | -1.6 |
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate (EC 2.5.1.48) |
| BBR_RS13145 | +0.2 |
| BBR_RS14595 | +1.2 |
| BBR_RS20795 | +0.3 |
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase:
(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2O→N-succinyl-2-amino-6-ketopimelate + coenzyme A (EC 2.3.1.117) |
| BBR_RS17990 | -4.5 |
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1) |
| BBR_RS14070 | -4.3 |
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13) |
| No genes |
Succinyldiaminopimelate transaminase (in reverse):
N-succinyl-2-amino-6-ketopimelate + L-glutamate→N-succinyl-L,L-2,6-diaminopimelate + 2-oxoglutarate (EC 2.6.1.17) |
| BBR_RS13900 | +1.2 |
| BBR_RS19050 | -0.8 |
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14) |
| BBR_RS15405 | -3.1 |
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate (EC 2.1.1.13) |
| No genes |
Succinyl-diaminopimelate desuccinylase:
N-succinyl-L,L-2,6-diaminopimelate + H2O→L,L-diaminopimelate + succinate (EC 3.5.1.18) |
| BBR_RS19470 | -1.7 |
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate (EC 5.1.1.7) |
| BBR_RS11480 | N.D. |
| BBR_RS13700 | -1.4 |
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2 (EC 4.1.1.20) |
| BBR_RS19555 | -1.2 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information