MetaCyc Pathway: superpathway of Clostridium acetobutylicum solventogenic fermentation in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes propionate (C)
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Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
Pf6N2E2_1380 N.D.
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
Pf6N2E2_1145 N.D.
Pf6N2E2_1675 +0.3
Pf6N2E2_1836 -0.2
Pf6N2E2_1851 +0.0
Pf6N2E2_1923 +0.2
Pf6N2E2_2113 -0.0
Pf6N2E2_2289 N.D.
Pf6N2E2_2539 -0.1
Pf6N2E2_2835 +0.2
Pf6N2E2_3492 +0.1
Pf6N2E2_5999 +0.5
Butyrate--acetoacetate CoA-transferase (in reverse):
acetoacetyl-CoA + butanoate→acetoacetate + butanoyl-CoA (EC 2.8.3.9)
No genes
Butyrate--acetoacetate CoA-transferase (in reverse):
acetoacetyl-CoA + acetate→acetoacetate + acetyl-CoA (EC 2.8.3.9)
No genes
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
Pf6N2E2_1380 N.D.
Pf6N2E2_1522 +0.5
Pf6N2E2_194 -0.2
Pf6N2E2_2802 -0.3
Pf6N2E2_3044 -0.2
Pf6N2E2_4819 -0.0
Pf6N2E2_5980 +0.3
Pf6N2E2_840 +1.1
Pf6N2E2_999 -0.5
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
Pf6N2E2_1722 +0.3
Pf6N2E2_1833 -0.1
Pf6N2E2_1850 +0.3
Pf6N2E2_1922 +0.1
Pf6N2E2_2290 N.D.
Pf6N2E2_3894 -0.0
Pf6N2E2_4690 -0.0
Pf6N2E2_6000 -0.0
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
Pf6N2E2_1013 -0.2
Pf6N2E2_1046 -0.0
Pf6N2E2_1834 +0.1
Pf6N2E2_1835 -0.2
Pf6N2E2_1840 +0.6
Pf6N2E2_1922 +0.1
Pf6N2E2_1934 +0.4
Pf6N2E2_1935 +0.1
Pf6N2E2_2290 N.D.
Pf6N2E2_2773 +0.1
Pf6N2E2_3894 -0.0
Pf6N2E2_5493 +0.0
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
No genes
Butanal dehydrogenase (in reverse):
butanoyl-CoA + NAD(P)H + H+→1-butanal + coenzyme A + NAD(P)+ (EC 1.2.1.57)
No genes
Alcohol dehydrogenase (NADP(+)) (in reverse):
1-butanal + NADPH + H+→butan-1-ol + NADP+ (EC 1.1.1.2)
No genes
1-butanal + NADH + H+→butan-1-ol + NAD+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information