| Reactions and Genes | propionate (C) |
|---|
| remove |
| a 2,3,4-saturated fatty acid + ATP + coenzyme A→a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate |
| No genes |
Acyl-CoA oxidase:
a 2,3,4-saturated fatty acyl CoA + dioxygen→a (2E)-2-enoyl-CoA + hydrogen peroxide (EC 1.3.3.6) |
| No genes |
Enoyl-CoA hydratase (in reverse):
a (2E)-2-enoyl-CoA + H2O→a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA (EC 4.2.1.17) |
| SO0021 (fadB) | -0.7 |
| SO0572 | -0.2 |
| SO1680 | -0.4 |
| SO1681 | -5.6 |
| SO3088 | +0.3 |
| SO3908 | +0.0 |
3-hydroxyacyl-CoA dehydrogenase:
a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA + NAD+→a 2,3,4-saturated 3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35) |
| SO0021 (fadB) | -0.7 |
| SO3088 | +0.3 |
Acetyl-CoA C-acyltransferase (in reverse):
a 2,3,4-saturated 3-oxoacyl-CoA + coenzyme A→a 2,3,4-saturated fatty acyl CoA + acetyl-CoA (EC 2.3.1.16) |
| SO0020 (fadA) | -0.3 |
| SO1677 (atoB) | -0.5 |
| SO3089 | -0.2 |
Citrate (Si)-synthase:
acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3) |
| SO1926 (gltA) | -5.1 |
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3) |
| SO0343 (acnA) | -5.9 |
| SO0432 (acnB) | N.D. |
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3) |
| SO0343 (acnA) | -5.9 |
| SO0432 (acnB) | N.D. |
Isocitrate lyase:
D-threo-isocitrate→glyoxylate + succinate (EC 4.1.3.1) |
| SO1484 (aceA) | -2.8 |
Malate synthase:
acetyl-CoA + glyoxylate + H2O→(S)-malate + coenzyme A + H+ (EC 2.3.3.9) |
| SO1483 (aceB) | -1.5 |
| SO4706 | +0.0 |
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1) |
| No genes |
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2) |
| SO2222 | N.D. |
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38) |
| SO0770 (mdh) | -4.9 |
| SO3855 (sfcA) | +0.3 |
Phosphoenolpyruvate carboxykinase (ATP):
oxaloacetate + ATP→phosphoenolpyruvate + ADP + CO2 (EC 4.1.1.49) |
| SO0162 (pckA) | +1.2 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information