MetaCyc Pathway: superpathway of tetrahydrofolate biosynthesis in Pseudomonas stutzeri RCH2

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Reactions and Genes butyrate (C)
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GTP cyclohydrolase I:
GTP + H2O→7,8-dihydroneopterin 3'-triphosphate + formate + H+
(EC 3.5.4.16)
Psest_1992 N.D.
Psest_2386 +0.2
Aminodeoxychorismate synthase:
chorismate + L-glutamine→4-amino-4-deoxychorismate + L-glutamate
(EC 2.6.1.85)
Psest_2326 -0.0
Psest_3649 -2.5
Aminodeoxychorismate lyase:
4-amino-4-deoxychorismate→4-aminobenzoate + H+ + pyruvate
(EC 4.1.3.38)
Psest_1691 -0.8
7,8-dihydroneopterin 3'-triphosphate + H2O→7,8-dihydroneopterin 3'-phosphate + diphosphate + H+ (EC 3.6.1.67)
No genes
7,8-dihydroneopterin 3'-phosphate + H2O→D-erythro-7,8-dihydroneopterin + phosphate
No genes
Dihydroneopterin aldolase:
D-erythro-7,8-dihydroneopterin→6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde
(EC 4.1.2.25)
Psest_3677 N.D.
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase:
6-(hydroxymethyl)-7,8-dihydropterin + ATP→(7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H+
(EC 2.7.6.3)
Psest_3676 N.D.
Psest_0997 N.D.
Dihydropteroate synthase:
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate→7,8-dihydropteroate + diphosphate
(EC 2.5.1.15)
Psest_0973 N.D.
Dihydrofolate synthase:
7,8-dihydropteroate + ATP + L-glutamate→7,8-dihydrofolate monoglutamate + ADP + H+ + phosphate
(EC 6.3.2.12)
Psest_2582 N.D.
Dihydrofolate reductase (in reverse):
a 7,8-dihydrofolate + NADPH + H+→a tetrahydrofolate + NADP+
(EC 1.5.1.3)
Psest_0229 N.D.
Psest_3204 -2.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information