MetaCyc Pathway: siroheme biosynthesis in Pseudomonas stutzeri RCH2

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Reactions and Genes nitrite (N)
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Uroporphyrinogen-III C-methyltransferase:
uroporphyrinogen-III + S-adenosyl-L-methionine→precorrin-1 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.107)
Psest_1925 -2.0
Psest_2037 -2.3
Psest_3746 N.D.
Psest_0788 +0.5
Psest_0810 -0.1
Uroporphyrinogen-III C-methyltransferase:
precorrin-1 + S-adenosyl-L-methionine→precorrin-2 + S-adenosyl-L-homocysteine (EC 2.1.1.107)
Psest_1925 -2.0
Psest_2037 -2.3
Psest_3746 N.D.
Psest_0788 +0.5
Psest_0810 -0.1
Precorrin-2 dehydrogenase:
precorrin-2 + NAD+→sirohydrochlorin + NADH + 2 H+ (EC 1.3.1.76)
Psest_1925 -2.0
Psest_2037 -2.3
Psest_0810 -0.1
Sirohydrochlorin ferrochelatase:
sirohydrochlorin + Fe2+→siroheme + 2 H+ (EC 4.99.1.4)
Psest_2037 -2.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information