MetaCyc Pathway: L-glutamate and L-glutamine biosynthesis in Marinobacter adhaerens HP15

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Reactions and Genes m.b. Cisplatin 0.025 mg/ml
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Glutamate dehydrogenase (NAD(P)(+)) (in reverse):
2-oxoglutarate + ammonium + NAD(P)H + H+→L-glutamate + NAD(P)+ + H2O (EC 1.4.1.3)
No genes
Glutamate synthase (ferredoxin) (in reverse):
2-oxoglutarate + L-glutamine + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→2 L-glutamate + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.4.7.1)
HP15_1128 -0.0
Glutamate synthase (NADH) (in reverse):
2-oxoglutarate + L-glutamine + NADH + H+→2 L-glutamate + NAD+ (EC 1.4.1.14)
HP15_482 N.D.
HP15_483 N.D.
Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+ (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
HP15_1128 -0.0
HP15_1272 N.D.
HP15_1851 +0.1
HP15_1914 +0.1
HP15_2050 N.D.
HP15_2261 N.D.
HP15_2338 +0.4
HP15_2343 -0.0
HP15_2456 N.D.
HP15_2457 N.D.
HP15_2458 N.D.
HP15_2620 -0.0
HP15_2733 -1.8
HP15_3077 N.D.
HP15_3078 -3.5
HP15_3288 -0.8
HP15_3289 -0.9
HP15_3379 -0.1
HP15_3525 -0.1
HP15_3543 -0.0
HP15_3635 -0.2
HP15_3901 +0.3
HP15_4085 -0.0
HP15_p187g60 +0.0
HP15_482 N.D.
HP15_483 N.D.
HP15_898 +0.3
Glutamate--ammonia ligase:
L-glutamate + ammonium + ATP→L-glutamine + ADP + H+ + phosphate (EC 6.3.1.2)
HP15_3156 +0.2
HP15_428 N.D.
HP15_942 +0.1
Glutamate dehydrogenase (NADP(+)) (in reverse):
2-oxoglutarate + ammonium + NADPH + H+→L-glutamate + NADP+ + H2O (EC 1.4.1.4)
HP15_483 N.D.
Glutamate synthase (NADPH) (in reverse):
2-oxoglutarate + ammonia + NADPH + 2 H+→L-glutamate + NADP+ + H2O (EC 1.4.1.13; 1.4.1.14)
HP15_2261 N.D.
HP15_2620 -0.0
HP15_2733 -1.8
HP15_3379 -0.1
HP15_3525 -0.1
HP15_3635 -0.2
HP15_3901 +0.3
HP15_4085 -0.0
HP15_482 N.D.
HP15_483 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information