MetaCyc Pathway: superpathway of L-phenylalanine biosynthesis in Burkholderia phytofirmans PsJN

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Reactions and Genes P. phyto PHYTO2 MOI 1
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
BPHYT_RS03535 -0.2
BPHYT_RS23245 -0.6
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
BPHYT_RS17885 +0.4
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
BPHYT_RS12675 N.D.
BPHYT_RS17005 N.D.
BPHYT_RS20430 -0.4
BPHYT_RS22680 -0.1
BPHYT_RS27380 N.D.
BPHYT_RS28845 +0.2
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
BPHYT_RS16975 -0.2
BPHYT_RS22685 -0.6
BPHYT_RS27375 -0.2
BPHYT_RS28720 +0.2
BPHYT_RS30065 -0.5
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
BPHYT_RS13350 +0.2
BPHYT_RS17890 -2.5
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
BPHYT_RS14895 -0.5
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
BPHYT_RS13705 -0.0
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
BPHYT_RS14910 -0.2
BPHYT_RS15260 +0.1
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
BPHYT_RS14910 -0.2
BPHYT_RS19370 -0.2
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
BPHYT_RS00155 +0.0
BPHYT_RS02830 -0.1
BPHYT_RS04100 N.D.
BPHYT_RS05430 -0.3
BPHYT_RS05975 -0.2
BPHYT_RS06770 +0.2
BPHYT_RS06900 -0.4
BPHYT_RS08040 +0.1
BPHYT_RS08950 -0.2
BPHYT_RS09580 +0.6
BPHYT_RS10265 -0.2
BPHYT_RS10440 -1.2
BPHYT_RS13065 -0.1
BPHYT_RS13450 -2.1
BPHYT_RS14905 +0.3
BPHYT_RS15405 -0.4
BPHYT_RS15820 -0.2
BPHYT_RS17705 +1.2
BPHYT_RS21060 +0.6
BPHYT_RS21560 +0.0
BPHYT_RS21610 +0.2
BPHYT_RS21730 -0.2
BPHYT_RS22065 +0.0
BPHYT_RS22425 +1.1
BPHYT_RS26535 +0.3
BPHYT_RS26755 -0.3
BPHYT_RS27000 +0.2
BPHYT_RS28370 +0.0
BPHYT_RS28685 -0.9
BPHYT_RS28695 +0.4
BPHYT_RS30590 +0.8
BPHYT_RS30680 -0.3
BPHYT_RS32285 -0.2
BPHYT_RS32640 +0.2
BPHYT_RS35285 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information