MetaCyc Pathway: ureide biosynthesis in Pseudomonas fluorescens SBW25-INTG

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Reactions and Genes Xanthosine (C)
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IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
PFLU_RS10605 +0.2
PFLU_RS24735 N.D.
5'-nucleotidase:
XMP + H2O→xanthosine + phosphate (EC 3.1.3.5)
PFLU_RS06415 -0.4
PFLU_RS08400 +0.1
PFLU_RS10890 +0.1
Purine-nucleoside phosphorylase:
xanthosine + phosphate→xanthine + α-D-ribose-1-phosphate (EC 2.4.2.1)
PFLU_RS28715 +0.1
Xanthine dehydrogenase:
xanthine + NAD+ + H2O→urate + NADH + H+ (EC 1.17.1.4)
PFLU_RS22500 -2.6
PFLU_RS22505 -2.8
PFLU_RS26280 +0.3
PFLU_RS26285 +0.0
Urate oxidase:
urate + dioxygen + H2O→(S)-5-hydroxyisourate + hydrogen peroxide (EC 1.7.3.3)
PFLU_RS04925 -0.2
PFLU_RS06770 -0.2
PFLU_RS21385 -2.9
Hydroxyisourate hydrolase:
(S)-5-hydroxyisourate + H2O→(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+ (EC 3.5.2.17)
PFLU_RS00975 +0.4
PFLU_RS21380 -3.5
(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+→(S)-(+)-allantoin + CO2 (EC 4.1.1.97)
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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information