MetaCyc Pathway: L-glutamate degradation V (via hydroxyglutarate) in Pseudomonas fluorescens SBW25-INTG

Add experiment(s):


Reactions and Genes L-Carnitine (C)
remove
Glutamate dehydrogenase:
L-glutamate + NAD+ + H2O→2-oxoglutarate + ammonium + NADH + H+ (EC 1.4.1.2)
PFLU_RS17095 +0.1
2-oxoglutarate + NADH + H+→(R)-2-hydroxyglutarate + NAD+ (EC 1.1.1.399)
PFLU_RS28695 -0.9
Glutaconate CoA-transferase:
(R)-2-hydroxyglutarate + acetyl-CoA→(R)-2-hydroxyglutaryl-CoA + acetate (EC 2.8.3.12)
PFLU_RS06725 +0.4
PFLU_RS06730 -0.4
(R)-2-hydroxyglutaryl-CoA→(E)-glutaconyl-CoA + H2O (EC 4.2.1.167)
No genes
(E)-glutaconyl-CoA[in] + Na+[in] + H+[in]→crotonyl-CoA[in] + CO2[in] + Na+[out] (EC 7.2.4.5)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
PFLU_RS07105 +0.3
PFLU_RS07650 -2.2
PFLU_RS08485 +0.3
PFLU_RS10835 +0.3
PFLU_RS12025 -0.3
PFLU_RS24260 +0.2
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
No genes
Propionate CoA-transferase:
butanoyl-CoA + acetate→acetyl-CoA + butanoate (EC 2.8.3.1; 2.8.3.8)
No genes
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
PFLU_RS07650 -2.2
PFLU_RS11090 +0.3
PFLU_RS22840 +0.4
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
PFLU_RS03225 +0.0
PFLU_RS06735 -0.5
PFLU_RS07655 -0.2
PFLU_RS10575 -1.6
PFLU_RS14765 -0.7
PFLU_RS16065 +0.1
PFLU_RS17190 -0.3
PFLU_RS21180 +0.3
PFLU_RS22845 -0.8

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information