| Reactions and Genes | Ying_AminoAcid20 rep A; time point 2 |
|---|
| remove |
| L-phenylalanine + L-serine + 2 ATP→cyclo(L-phenylalanyl-L-seryl) + 2 ADP + 2 H+ + 2 phosphate |
| No genes |
| cyclo(L-phenylalanyl-L-seryl) + 2 dioxygen + 2 a reduced [NADPH-hemoprotein reductase]→3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + 2 an oxidized [NADPH-hemoprotein reductase] + 2 H2O |
| No genes |
Glutathione transferase:
3-benzyl-3,6-dihydroxy-6-(hydroxymethyl)-diketopiperazine + 2 glutathione→3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine + 2 H2O (EC 2.5.1.18) |
| Pf6N2E2_1445 | -0.2 |
| Pf6N2E2_1553 | -0.7 |
| Pf6N2E2_1561 | +0.2 |
| Pf6N2E2_1619 | -0.2 |
| Pf6N2E2_2148 | +0.3 |
| Pf6N2E2_2168 | -1.5 |
| Pf6N2E2_303 | +0.0 |
| Pf6N2E2_395 | -0.2 |
| Pf6N2E2_4178 | -0.3 |
| Pf6N2E2_4235 | +0.1 |
| Pf6N2E2_4428 | +0.3 |
| Pf6N2E2_509 | -0.5 |
| Pf6N2E2_5292 | -1.4 |
| Pf6N2E2_5412 | +0.1 |
| Pf6N2E2_5517 | -1.2 |
| Pf6N2E2_5974 | -0.2 |
| Pf6N2E2_6007 | +0.1 |
| Pf6N2E2_933 | +0.0 |
| 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine→3-benzyl-3,6 -bis(cysteinylglycine)- 6-(hydroxymethyl)-diketopiperazine + 2 5-oxo-L-proline (EC 4.3.2.9) |
| No genes |
Membrane dipeptidase:
3-benzyl-3,6 -bis(cysteinylglycine)- 6-(hydroxymethyl)-diketopiperazine + 2 H2O→3-benzyl-3,6 -bis(cysteinyl)- 6-(hydroxymethyl)-diketopiperazine + 2 glycine (EC 3.4.13.19) |
| Pf6N2E2_4700 | -1.0 |
| 3-benzyl-3,6 -bis(cysteinyl)- 6-(hydroxymethyl)-diketopiperazine + 2 H2O→3-benzyl-3,6 -dithio-6-(hydroxymethyl)-diketopiperazine + 2 ammonium + 2 pyruvate |
| No genes |
Thiol oxidase:
3-benzyl-3,6 -dithio-6-(hydroxymethyl)-diketopiperazine + dioxygen→3-benzyl-3,6 -disulfide-6-(hydroxymethyl)-diketopiperazine + hydrogen peroxide (EC 1.8.3.2) |
| No genes |
| 3-benzyl-3,6 -disulfide-6-(hydroxymethyl)-diketopiperazine→N-desmethyl-gliotoxin |
| No genes |
| N-desmethyl-gliotoxin + S-adenosyl-L-methionine→gliotoxin + S-adenosyl-L-homocysteine + H+ |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information