MetaCyc Pathway: superpathway of purines degradation in plants in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes Ying_Nucleobase14 rep C; time point 1
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Adenosine-phosphate deaminase:
AMP + H+ + H2O→IMP + ammonium (EC 3.5.4.17; 3.5.4.6)
No genes
5'-nucleotidase:
GMP + H2O→guanosine + phosphate (EC 3.1.3.5)
Pf6N2E2_2467 -0.3
Pf6N2E2_3040 +0.3
Pf6N2E2_3887 -0.2
Guanosine deaminase:
guanosine + H+ + H2O→xanthosine + ammonium (EC 3.5.4.15)
No genes
IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
Pf6N2E2_1116 -0.3
Pf6N2E2_2138 -0.1
Pf6N2E2_3165 N.D.
5'-nucleotidase:
IMP + H2O→inosine + phosphate (EC 3.1.3.5; 3.1.3.99)
Pf6N2E2_2467 -0.3
Pf6N2E2_3040 +0.3
Pf6N2E2_3887 -0.2
Purine nucleosidase:
guanosine + H2O→guanine + D-ribofuranose (EC 3.2.2.1)
Pf6N2E2_167 +0.1
Guanine deaminase:
guanine + H+ + H2O→xanthine + ammonium (EC 3.5.4.3)
Pf6N2E2_2339 +0.1
Pf6N2E2_3473 -0.1
Inosine nucleosidase:
inosine + H2O→hypoxanthine + D-ribofuranose (EC 3.2.2.2)
Pf6N2E2_167 +0.1
5'-nucleotidase:
XMP + H2O→xanthosine + phosphate (EC 3.1.3.5)
Pf6N2E2_2467 -0.3
Pf6N2E2_3040 +0.3
Xanthine dehydrogenase:
hypoxanthine + NAD+ + H2O→xanthine + NADH + H+ (EC 1.17.1.4)
Pf6N2E2_2336 -0.5
Pf6N2E2_2337 -1.1
Purine nucleosidase:
xanthosine + H2O→xanthine + D-ribofuranose (EC 3.2.2.1)
Pf6N2E2_167 +0.1
Xanthine dehydrogenase:
xanthine + NAD+ + H2O→urate + NADH + H+ (EC 1.17.1.4)
Pf6N2E2_2336 -0.5
Pf6N2E2_2337 -1.1
Urate oxidase:
urate + dioxygen + H2O→(S)-5-hydroxyisourate + hydrogen peroxide (EC 1.7.3.3)
Pf6N2E2_1242 +0.2
Pf6N2E2_5390 +0.0
Pf6N2E2_5805 -1.1
Hydroxyisourate hydrolase:
(S)-5-hydroxyisourate + H2O→(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+ (EC 3.5.2.17)
Pf6N2E2_5807 -1.2
(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+→(S)-(+)-allantoin + CO2 (EC 4.1.1.97)
No genes
Allantoinase:
(S)-(+)-allantoin + H2O→allantoate + H+ (EC 3.5.2.5)
No genes
Allantoicase:
allantoate + H2O→(S)-ureidoglycolate + urea (EC 3.5.3.4)
Pf6N2E2_5803 -2.1
Ureidoglycolate lyase:
(S)-ureidoglycolate→glyoxylate + urea (EC 4.3.2.3)
Pf6N2E2_5802 -1.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information