MetaCyc Pathway: L-tyrosine degradation I in Pseudomonas fluorescens SBW25-INTG

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Reactions and Genes L-tyrosine (C) 10 mM
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Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
PFLU_RS04475 -1.0
PFLU_RS08100 +0.0
PFLU_RS08510 -0.1
PFLU_RS09125 +0.2
PFLU_RS10980 +0.4
PFLU_RS13455 +0.1
PFLU_RS15480 -0.0
PFLU_RS16880 -0.1
PFLU_RS17055 +0.1
PFLU_RS17810 -0.1
PFLU_RS19680 -0.2
PFLU_RS20660 +0.2
PFLU_RS21080 +0.0
PFLU_RS21355 -0.0
PFLU_RS21880 -3.2
PFLU_RS22640 +0.1
PFLU_RS22895 +1.7
PFLU_RS24775 -0.2
PFLU_RS25195 +0.0
PFLU_RS29405 -0.1
PFLU_RS29850 -0.1
4-hydroxyphenylpyruvate dioxygenase:
3-(4-hydroxyphenyl)pyruvate + dioxygen→homogentisate + CO2 (EC 1.13.11.27)
PFLU_RS14610 -3.3
PFLU_RS26370 +0.0
Homogentisate 1,2-dioxygenase:
homogentisate + dioxygen→4-maleyl-acetoacetate + H+ (EC 1.13.11.5)
PFLU_RS05085 -4.3
Maleylacetoacetate isomerase:
4-maleyl-acetoacetate→4-fumaryl-acetoacetate (EC 5.2.1.2)
PFLU_RS05095 -3.9
Fumarylacetoacetase:
4-fumaryl-acetoacetate + H2O→acetoacetate + fumarate + H+ (EC 3.7.1.2)
PFLU_RS05090 -3.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information