MetaCyc Pathway: glycine cleavage in Pseudomonas fluorescens SBW25-INTG

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Reactions and Genes L-Isoleucine (C) 10 mM
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a [glycine-cleavage complex H protein] N6-[(R)-lipoyl]-L-lysine + glycine + H+→a [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + CO2 (EC 1.4.1.27; 1.4.4.2)
PFLU_RS24000 +0.0
a [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + a tetrahydrofolate→a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine + ammonium + a 5,10-methylenetetrahydrofolate (EC 1.4.1.27; 2.1.2.10)
PFLU_RS11440 -0.1
PFLU_RS11455 -0.4
PFLU_RS23995 +0.2
PFLU_RS24010 -0.1
PFLU_RS28910 -0.0
PFLU_RS28915 -0.0
a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine + NAD+→a [glycine-cleavage complex H protein] N6-[(R)-lipoyl]-L-lysine + NADH + H+ (EC 1.4.1.27; 1.8.1.4)
PFLU_RS08965 N.D.
PFLU_RS19370 -2.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information