MetaCyc Pathway: benzoate biosynthesis I (CoA-dependent, β-oxidative) in Pseudomonas fluorescens SBW25-INTG

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Reactions and Genes propionate 20 mM (C)
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Phenylalanine ammonia-lyase:
L-phenylalanine→trans-cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
No genes
trans-cinnamate + ATP + coenzyme A→(E)-cinnamoyl-CoA + AMP + diphosphate
No genes
Enoyl-CoA hydratase (in reverse):
(E)-cinnamoyl-CoA + H2O→(S)-3-hydroxy-3-phenylpropanoyl-CoA (EC 4.2.1.17)
PFLU_RS07105 -1.9
PFLU_RS07650 -2.4
PFLU_RS08485 -1.1
PFLU_RS10835 +0.1
PFLU_RS12025 +0.3
PFLU_RS13550 +0.2
PFLU_RS14775 -0.1
PFLU_RS14785 -0.5
PFLU_RS16080 -0.2
PFLU_RS22820 +0.3
PFLU_RS22840 +0.4
PFLU_RS24260 +0.2
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-3-phenylpropanoyl-CoA + NAD+→3-oxo-3-phenylpropanoyl-CoA + NADH + H+ (EC 1.1.1.35)
PFLU_RS07650 -2.4
PFLU_RS11090 +0.2
PFLU_RS22840 +0.4
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-3-phenylpropanoyl-CoA + coenzyme A→benzoyl-CoA + acetyl-CoA (EC 2.3.1.16)
PFLU_RS03225 -0.0
PFLU_RS06735 -0.8
PFLU_RS07655 -1.3
PFLU_RS10575 -0.2
PFLU_RS14765 +0.1
PFLU_RS16065 -0.3
PFLU_RS17190 +0.1
PFLU_RS21180 -0.2
PFLU_RS22845 -0.3
benzoyl-CoA + H2O→benzoate + coenzyme A + H+
No genes
Benzoate--CoA ligase:
benzoate + ATP + coenzyme A→benzoyl-CoA + AMP + diphosphate (EC 6.2.1.25)
No genes
benzoyl-CoA + benzyl alcohol→benzyl benzoate + coenzyme A (EC 2.3.1.196)
No genes
benzyl benzoate + H2O→benzoate + benzyl alcohol + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information