MetaCyc Pathway: superpathway of L-threonine biosynthesis in Pseudomonas fluorescens SBW25-INTG

Add experiment(s):


Reactions and Genes L-tyrosine 10 mM (C)
remove
Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
PFLU_RS08510 +0.3
PFLU_RS09125 -0.1
PFLU_RS10980 -0.3
PFLU_RS13455 -0.0
PFLU_RS15480 +0.1
PFLU_RS16880 -0.1
PFLU_RS17055 -0.0
PFLU_RS17810 -0.0
PFLU_RS19680 -0.5
PFLU_RS21080 -0.0
PFLU_RS21355 +0.1
PFLU_RS21880 -3.7
PFLU_RS22640 +0.1
PFLU_RS22895 +1.3
PFLU_RS24775 -0.0
PFLU_RS29405 +0.1
PFLU_RS29850 +0.0
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
PFLU_RS23265 -0.1
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
PFLU_RS06680 +0.2
PFLU_RS20555 -0.1
PFLU_RS20560 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
PFLU_RS09890 -0.1
PFLU_RS24550 N.D.
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
PFLU_RS00385 N.D.
PFLU_RS22735 -0.2
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
PFLU_RS09885 -0.3
PFLU_RS24545 N.D.

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information