MetaCyc Pathway: adipate biosynthesis in Rhodopseudomonas palustris CGA009

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Reactions and Genes Sebacic (C); anaerobic
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3-oxoadipyl-CoA thiolase:
acetyl-CoA + succinyl-CoA→3-oxoadipoyl-CoA + coenzyme A (EC 2.3.1.174)
TX73_002660 +0.1
3-hydroxyacyl-CoA dehydrogenase (in reverse):
3-oxoadipoyl-CoA + NADH + H+→(3S)-hydroxyadipyl-CoA + NAD+ (EC 1.1.1.35)
TX73_004220 -0.0
TX73_008775 -0.1
TX73_011910 -0.1
TX73_018155 -0.0
TX73_019255 -1.4
Enoyl-CoA hydratase:
(3S)-hydroxyadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA + H2O (EC 4.2.1.17)
TX73_001990 -0.1
TX73_002165 -0.0
TX73_002395 +0.1
TX73_002500 +0.1
TX73_002510 +0.0
TX73_003370 +0.0
TX73_003500 -0.0
TX73_004220 -0.0
TX73_004930 +0.2
TX73_006355 +0.1
TX73_007240 +0.4
TX73_008780 +0.2
TX73_008810 -0.0
TX73_009040 -0.1
TX73_009055 +0.3
TX73_009075 +0.1
TX73_009185 +0.1
TX73_009315 -0.2
TX73_011065 +0.2
TX73_011975 +0.0
TX73_014325 +0.2
TX73_017085 -0.0
TX73_017810 -0.3
TX73_017840 -0.3
TX73_017875 +0.2
TX73_019255 -1.4
TX73_019650 -0.1
TX73_022390 -0.1
TX73_022490 +0.3
(2E)-5-carboxy-2-pentenoyl-CoA + FADH2→adipoyl-CoA + FAD + H+
TX73_017845 -0.0
Succinate--CoA ligase (ADP-forming) (in reverse):
adipoyl-CoA + ADP + phosphate→adipate + ATP + coenzyme A (EC 6.2.1.5)
TX73_000985 N.D.
TX73_000990 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information