MetaCyc Pathway: (8E,10E)-dodeca-8,10-dienol biosynthesis in Rhodopseudomonas palustris CGA009

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Reactions and Genes Sebacic (C); anaerobic
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palmitoyl-CoA[in] + an oxidized electron-transfer flavoprotein[in] + H+[in]→(2E)-hexadec-2-enoyl-CoA[in] + a reduced electron-transfer flavoprotein[in] (EC 1.3.8.9)
No genes
(8E,10E)-dodeca-8,10-dienoate + 2 NADPH + 3 H+→(8E,10E)-dodeca-8,10-dienol + 2 NADP+ + H2O
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-hexadec-2-enoyl-CoA + H2O→(S)-3-hydroxyhexadecanoyl-CoA (EC 4.2.1.17)
TX73_001990 -0.1
TX73_002165 -0.0
TX73_002395 +0.1
TX73_002500 +0.1
TX73_002510 +0.0
TX73_003370 +0.0
TX73_003500 -0.0
TX73_004220 -0.0
TX73_004930 +0.2
TX73_006355 +0.1
TX73_007240 +0.4
TX73_008780 +0.2
TX73_008810 -0.0
TX73_009040 -0.1
TX73_009055 +0.3
TX73_009075 +0.1
TX73_009185 +0.1
TX73_009315 -0.2
TX73_011065 +0.2
TX73_011975 +0.0
TX73_014325 +0.2
TX73_017085 -0.0
TX73_017810 -0.3
TX73_017840 -0.3
TX73_017875 +0.2
TX73_019255 -1.4
TX73_019650 -0.1
TX73_022390 -0.1
TX73_022490 +0.3
Long-chain-3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxyhexadecanoyl-CoA + NAD+→3-oxopalmitoyl-CoA + NADH + H+ (EC 1.1.1.211)
TX73_004220 -0.0
TX73_018155 -0.0
TX73_019255 -1.4
Acetyl-CoA C-myristoyltransferase (in reverse):
3-oxopalmitoyl-CoA + coenzyme A→myristoyl-CoA + acetyl-CoA (EC 2.3.1.155)
TX73_011915 +0.2
TX73_017920 +0.1
TX73_017940 -0.1
myristoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-tetradec-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-tetradec-2-enoyl-CoA + H2O→(S)-3-hydroxytetradecanoyl-CoA (EC 4.2.1.17)
TX73_001990 -0.1
TX73_002165 -0.0
TX73_002395 +0.1
TX73_002500 +0.1
TX73_002510 +0.0
TX73_003370 +0.0
TX73_003500 -0.0
TX73_004220 -0.0
TX73_004930 +0.2
TX73_006355 +0.1
TX73_007240 +0.4
TX73_008780 +0.2
TX73_008810 -0.0
TX73_009040 -0.1
TX73_009055 +0.3
TX73_009075 +0.1
TX73_009185 +0.1
TX73_009315 -0.2
TX73_011065 +0.2
TX73_011975 +0.0
TX73_014325 +0.2
TX73_017085 -0.0
TX73_017810 -0.3
TX73_017840 -0.3
TX73_017875 +0.2
TX73_019255 -1.4
TX73_019650 -0.1
TX73_022390 -0.1
TX73_022490 +0.3
(S)-3-hydroxytetradecanoyl-CoA + NAD+→3-oxomyristoyl-CoA + NADH + H+
TX73_004220 -0.0
TX73_018155 -0.0
TX73_019255 -1.4
Acetyl-CoA C-acyltransferase (in reverse):
3-oxomyristoyl-CoA + coenzyme A→lauroyl-CoA + acetyl-CoA (EC 2.3.1.16)
TX73_002660 +0.1
TX73_002750 -0.1
TX73_004215 -0.1
TX73_008765 +0.2
TX73_011915 +0.2
TX73_017920 +0.1
TX73_017940 -0.1
TX73_019245 -1.2
TX73_022530 +0.0
lauroyl-CoA + 2 a ferrocytochrome b5 + dioxygen + 2 H+→(9E)-dodecenoyl-CoA + 2 a ferricytochrome b5 + 2 H2O
No genes
(9E)-dodecenoyl-CoA + 2 a ferrocytochrome b5 + dioxygen + 2 H+→(8E,10E)-dodeca-8,10-dienoyl-CoA + 2 a ferricytochrome b5 + 2 H2O
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information