MetaCyc Pathway: pyruvate fermentation to butanol II (engineered) in Rhodopseudomonas palustris CGA009

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Reactions and Genes Sebacic (C); anaerobic
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
TX73_002660 +0.1
TX73_002750 -0.1
TX73_004215 -0.1
TX73_008765 +0.2
TX73_009030 +0.1
TX73_011915 +0.2
TX73_016520 -0.0
TX73_017920 +0.1
TX73_017940 -0.1
TX73_019245 -1.2
TX73_022530 +0.0
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
TX73_004220 -0.0
TX73_008775 -0.1
TX73_011910 -0.1
TX73_018155 -0.0
TX73_019255 -1.4
TX73_024670 -0.8
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
TX73_001990 -0.1
TX73_002165 -0.0
TX73_002395 +0.1
TX73_002500 +0.1
TX73_002510 +0.0
TX73_003370 +0.0
TX73_004930 +0.2
TX73_006355 +0.1
TX73_007240 +0.4
TX73_008810 -0.0
TX73_009040 -0.1
TX73_009055 +0.3
TX73_009185 +0.1
TX73_009315 -0.2
TX73_011975 +0.0
TX73_014325 +0.2
TX73_017085 -0.0
TX73_019255 -1.4
TX73_019650 -0.1
TX73_022390 -0.1
TX73_022490 +0.3
Trans-2-enoyl-CoA reductase (NAD(+)) (in reverse):
crotonyl-CoA + NADH + H+→butanoyl-CoA + NAD+ (EC 1.3.1.44)
TX73_002490 +0.0
TX73_003380 +0.1
TX73_003825 -0.1
TX73_005120 -0.0
TX73_006350 +0.1
TX73_008280 +0.1
TX73_008790 +0.0
TX73_008795 +0.1
TX73_008800 +0.0
TX73_009060 +0.1
TX73_011025 +0.3
TX73_011920 +0.2
TX73_019235 -1.8
TX73_023655 -0.0
Butanal dehydrogenase (in reverse):
butanoyl-CoA + NAD(P)H + H+→1-butanal + coenzyme A + NAD(P)+ (EC 1.2.1.57)
No genes
1-butanal + NADH + H+→butan-1-ol + NAD+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information