MetaCyc Pathway: superpathway of Clostridium acetobutylicum solventogenic fermentation in Rhodopseudomonas palustris CGA009

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Reactions and Genes Sebacic (C); anaerobic
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Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
No genes
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
TX73_002660 +0.1
TX73_002750 -0.1
TX73_004215 -0.1
TX73_008765 +0.2
TX73_009030 +0.1
TX73_011915 +0.2
TX73_016520 -0.0
TX73_017920 +0.1
TX73_017940 -0.1
TX73_019245 -1.2
TX73_022530 +0.0
Butyrate--acetoacetate CoA-transferase (in reverse):
acetoacetyl-CoA + butanoate→acetoacetate + butanoyl-CoA (EC 2.8.3.9)
No genes
Butyrate--acetoacetate CoA-transferase (in reverse):
acetoacetyl-CoA + acetate→acetoacetate + acetyl-CoA (EC 2.8.3.9)
No genes
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
TX73_001945 +0.0
TX73_003400 +0.1
TX73_003490 +0.1
TX73_005430 +0.0
TX73_006190 +0.0
TX73_010080 -0.1
TX73_010400 N.D.
TX73_015865 +0.1
TX73_018940 +0.2
TX73_020325 +0.2
TX73_025060 -0.1
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
TX73_004220 -0.0
TX73_008775 -0.1
TX73_011910 -0.1
TX73_018155 -0.0
TX73_019255 -1.4
TX73_024670 -0.8
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
TX73_001990 -0.1
TX73_002165 -0.0
TX73_002395 +0.1
TX73_002500 +0.1
TX73_002510 +0.0
TX73_003370 +0.0
TX73_004930 +0.2
TX73_006355 +0.1
TX73_007240 +0.4
TX73_008810 -0.0
TX73_009040 -0.1
TX73_009055 +0.3
TX73_009185 +0.1
TX73_009315 -0.2
TX73_011975 +0.0
TX73_014325 +0.2
TX73_017085 -0.0
TX73_019255 -1.4
TX73_019650 -0.1
TX73_022390 -0.1
TX73_022490 +0.3
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
No genes
Butanal dehydrogenase (in reverse):
butanoyl-CoA + NAD(P)H + H+→1-butanal + coenzyme A + NAD(P)+ (EC 1.2.1.57)
No genes
Alcohol dehydrogenase (NADP(+)) (in reverse):
1-butanal + NADPH + H+→butan-1-ol + NADP+ (EC 1.1.1.2)
No genes
1-butanal + NADH + H+→butan-1-ol + NAD+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information