MetaCyc Pathway: propanoate fermentation to 2-methylbutanoate in Rhodopseudomonas palustris CGA009

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Reactions and Genes Sebacic (C); anaerobic
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Propionate CoA-transferase:
propanoate + acetyl-CoA→acetate + propanoyl-CoA (EC 2.8.3.1)
No genes
Acetyl-CoA C-acyltransferase:
propanoyl-CoA + acetyl-CoA→2-methylacetoacetyl-CoA + coenzyme A (EC 2.3.1.16)
TX73_002660 +0.1
TX73_002750 -0.1
TX73_004215 -0.1
TX73_008765 +0.2
TX73_011915 +0.2
TX73_017920 +0.1
TX73_017940 -0.1
TX73_019245 -1.2
TX73_022530 +0.0
3-hydroxy-2-methylbutyryl-CoA dehydrogenase (in reverse):
2-methylacetoacetyl-CoA + NADH + H+→(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ (EC 1.1.1.178)
TX73_004220 -0.0
TX73_008775 -0.1
TX73_011910 -0.1
TX73_018155 -0.0
TX73_019255 -1.4
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA→(E)-2-methylcrotonoyl-CoA + H2O (EC 4.2.1.150)
TX73_001990 -0.1
TX73_002165 -0.0
TX73_002395 +0.1
TX73_002500 +0.1
TX73_002510 +0.0
TX73_003370 +0.0
TX73_004220 -0.0
TX73_004930 +0.2
TX73_006355 +0.1
TX73_007240 +0.4
TX73_008810 -0.0
TX73_009040 -0.1
TX73_009055 +0.3
TX73_009185 +0.1
TX73_009315 -0.2
TX73_011975 +0.0
TX73_014325 +0.2
TX73_017085 -0.0
TX73_019255 -1.4
TX73_019650 -0.1
TX73_022390 -0.1
TX73_022490 +0.3
(E)-2-methylcrotonoyl-CoA + a reduced electron-transfer flavoprotein→(2S)-2-methylbutanoyl-CoA + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.5)
No genes
(2S)-2-methylbutanoyl-CoA + H2O→2-methylbutanoate + coenzyme A + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information