MetaCyc Pathway: 2-allylmalonyl-CoA biosynthesis in Rhodopseudomonas palustris CGA009

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Reactions and Genes L-Leucine (C); anaerobic
remove
propanoyl-CoA + TcsB polyketide synthase→propanoyl-[TcsB polyketide synthase] + coenzyme A
No genes
malonyl-CoA + TcsA polyketide synthase→malonyl-[TcsA polyketide synthase] + coenzyme A
No genes
malonyl-[TcsA polyketide synthase] + propanoyl-[TcsB polyketide synthase] + H+→3-oxopentanoyl-[TcsA polyketide synthase] + CO2 + TcsB polyketide synthase
No genes
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
3-oxopentanoyl-[TcsA polyketide synthase] + NADPH + H+→(3R)-3-hydroxypentanoyl-[TcsA polyketide synthase] + NADP+ (EC 1.1.1.100)
TX73_000560 +0.3
TX73_002485 +0.2
TX73_003390 -2.9
TX73_004045 +0.2
TX73_004610 -0.1
TX73_004615 -0.1
TX73_008650 -0.1
TX73_008655 -0.1
TX73_008935 +0.2
TX73_011140 -0.1
TX73_012495 +0.3
TX73_015900 N.D.
TX73_016995 -0.0
TX73_017080 +0.3
TX73_017465 +0.2
TX73_017980 +0.3
TX73_018405 +0.2
TX73_018410 +0.0
TX73_020990 -0.5
TX73_023875 -0.0
TX73_024180 -0.0
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
(3R)-3-hydroxypentanoyl-[TcsA polyketide synthase]→(2E)-pent-2-enoyl-[TcsA polyketide synthase] + H2O (EC 4.2.1.59)
TX73_002210 N.D.
TX73_010415 +0.1
TX73_015090 N.D.
(2E)-pent-2-enoyl-[TcsA polyketide synthase] + CO2 + NADPH→2-carboxypentanoyl-[TcsA polyketide synthase] + NADP+
No genes
2-carboxypentanoyl-[TcsA polyketide synthase] + FAD + H+→2-allylmalonyl-[TcsA polyketide synthase] + FADH2
No genes
2-allylmalonyl-[TcsA polyketide synthase] + coenzyme A→2-allylmalonyl-CoA + TcsA polyketide synthase
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information