MetaCyc Pathway: 3-hydroxypropanoate/4-hydroxybutanate cycle in Rhodopseudomonas palustris CGA009

Add experiment(s):


Reactions and Genes Citraconic (C); anaerobic
remove
Carbonate dehydratase (in reverse):
CO2 + H2O→hydrogen carbonate + H+ (EC 4.2.1.1)
TX73_001200 -0.0
TX73_004095 +0.1
TX73_004120 -0.1
Biotin carboxylase:
hydrogen carbonate + ATP + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine→a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine + ADP + H+ + phosphate (EC 6.3.4.14)
TX73_007450 +0.1
TX73_012595 N.D.
TX73_012600 N.D.
TX73_016420 -4.3
a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine + acetyl-CoA→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
TX73_002635 N.D.
malonyl-CoA + NADPH + H+→3-oxopropanoate + coenzyme A + NADP+ (EC 1.2.1.75)
No genes
3-oxopropanoate + NADPH + H+→3-hydroxypropanoate + NADP+ (EC 1.1.1.298)
TX73_022205 -0.0
3-hydroxypropanoate + ATP + coenzyme A→3-hydroxypropanoyl-CoA + AMP + diphosphate (EC 6.2.1.36)
No genes
3-hydroxypropanoyl-CoA→acryloyl-CoA + H2O (EC 4.2.1.116)
TX73_009315 +0.1
TX73_011975 +0.2
TX73_019650 -0.1
acryloyl-CoA + NADPH + H+→propanoyl-CoA + NADP+ (EC 1.3.1.84)
TX73_005430 -0.1
TX73_024185 -0.1
Propionyl-CoA carboxylase:
hydrogen carbonate + propanoyl-CoA + ATP→(S)-methylmalonyl-CoA + ADP + H+ + phosphate (EC 6.4.1.3)
TX73_000370 N.D.
TX73_002635 N.D.
TX73_016420 -4.3
TX73_016565 -5.3
TX73_017885 -0.0
Methylmalonyl-CoA epimerase (in reverse):
(S)-methylmalonyl-CoA→(R)-methylmalonyl-CoA (EC 5.1.99.1)
TX73_015205 -2.1
Methylmalonyl-CoA mutase:
(R)-methylmalonyl-CoA→succinyl-CoA (EC 5.4.99.2)
TX73_009435 -4.6
TX73_009445 -4.2
succinyl-CoA + NADPH + H+→succinate semialdehyde + coenzyme A + NADP+ (EC 1.2.1.76)
No genes
succinate semialdehyde + NADPH + H+→4-hydroxybutanoate + NADP+ (EC 1.1.1.co)
No genes
4-hydroxybutanoate + ATP + coenzyme A→4-hydroxybutanoyl-CoA + AMP + diphosphate (EC 6.2.1.40)
No genes
4-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.120)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
TX73_001990 -0.0
TX73_002165 -0.1
TX73_002395 -0.1
TX73_002500 -0.3
TX73_002510 +0.1
TX73_003370 -0.2
TX73_004930 +0.2
TX73_006355 +0.0
TX73_007240 +0.3
TX73_008810 -0.2
TX73_009040 +0.1
TX73_009055 +0.0
TX73_009185 -0.1
TX73_009315 +0.1
TX73_011975 +0.2
TX73_014325 +0.2
TX73_017085 +0.2
TX73_019255 +0.1
TX73_019650 -0.1
TX73_022390 +0.0
TX73_022490 -0.1
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
TX73_004220 +0.0
TX73_008775 -0.0
TX73_011910 -0.1
TX73_018155 -0.2
TX73_019255 +0.1
TX73_024670 -0.8
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
TX73_002660 +0.2
TX73_002750 +0.0
TX73_004215 -0.1
TX73_008765 +0.2
TX73_009030 +0.1
TX73_011915 +0.1
TX73_016520 -0.0
TX73_017920 +0.2
TX73_017940 +0.1
TX73_019245 +0.2
TX73_022530 +0.1

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information