MetaCyc Pathway: oleate β-oxidation in Mycobacterium tuberculosis H37Rv

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Reactions and Genes propionate (C)
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Long-chain-fatty-acid--CoA ligase:
oleate + ATP + coenzyme A→oleoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
Rv0166 +0.1
Rv0214 +0.1
Rv0270 -0.1
Rv1013 -1.1
Rv1058 -1.4
Rv1427c +0.1
Rv2187 +0.0
Rv2505c +0.4
Rv3506 +0.1
Rv3513c +0.2
Rv3515c -0.3
Rv3561 -0.1
oleoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E,9Z)-octadec-2,9-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Enoyl-CoA hydratase (in reverse):
(2E,9Z)-octadec-2,9-enoyl-CoA + H2O→(S)-3-hydroxy-(9Z)-octadecenoyl-CoA (EC 4.2.1.17)
Rv0130 +0.0
Rv0222 -0.2
Rv0456c -0.0
Rv0632c -0.2
Rv0673 +0.2
Rv0675 -0.6
Rv0860 N.D.
Rv0905 -0.5
Rv0971c -0.4
Rv1070c +0.2
Rv1071c -0.1
Rv1136 N.D.
Rv1141c +0.1
Rv1142c -0.2
Rv1472 -0.0
Rv1935c -0.6
Rv2486 +0.2
Rv2679 -0.3
Rv2831 +0.2
Rv3039c +0.0
Rv3373 N.D.
Rv3374 -0.6
Rv3516 +0.0
Rv3550 +0.3
Rv3774 +0.0
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-(9Z)-octadecenoyl-CoA + NAD+→3-oxo-(9Z)-octadecenoyl-CoA + NADH + H+ (EC 1.1.1.35)
Rv0468 -0.3
Rv0860 N.D.
Rv1144 +0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-(9Z)-octadecenoyl-CoA + coenzyme A→acetyl-CoA + (7Z)-hexadecenoyl-CoA (EC 2.3.1.16)
Rv0243 -0.3
Rv0859 N.D.
Rv0914c +0.1
Rv1074c +0.1
Rv1135A N.D.
Rv1323 -0.3
Rv2790c +0.3
Rv3523 -0.0
Rv3546 -0.5
Rv3556c +0.1
(7Z)-hexadecenoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E,7Z)-hexadec-2,7-dienoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Enoyl-CoA hydratase (in reverse):
(2E,7Z)-hexadec-2,7-dienoyl-CoA + H2O→(S)-3-hydroxy-(7Z)-hexadecenoyl-CoA (EC 4.2.1.17)
Rv0130 +0.0
Rv0222 -0.2
Rv0456c -0.0
Rv0632c -0.2
Rv0673 +0.2
Rv0675 -0.6
Rv0860 N.D.
Rv0905 -0.5
Rv0971c -0.4
Rv1070c +0.2
Rv1071c -0.1
Rv1136 N.D.
Rv1141c +0.1
Rv1142c -0.2
Rv1472 -0.0
Rv1935c -0.6
Rv2486 +0.2
Rv2679 -0.3
Rv2831 +0.2
Rv3039c +0.0
Rv3373 N.D.
Rv3374 -0.6
Rv3516 +0.0
Rv3550 +0.3
Rv3774 +0.0
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-(7Z)-hexadecenoyl-CoA + NAD+→3-oxo-(7Z)-hexadecenoyl-CoA + NADH + H+ (EC 1.1.1.35)
Rv0468 -0.3
Rv0860 N.D.
Rv1144 +0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-(7Z)-hexadecenoyl-CoA + coenzyme A→acetyl-CoA + (5Z)-tetradecenoyl-CoA (EC 2.3.1.16)
Rv0243 -0.3
Rv0859 N.D.
Rv0914c +0.1
Rv1074c +0.1
Rv1135A N.D.
Rv1323 -0.3
Rv2790c +0.3
Rv3523 -0.0
Rv3546 -0.5
Rv3556c +0.1
(5Z)-tetradecenoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E,5Z)-tetradec-2,5-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Dodecenoyl-CoA isomerase:
(2E,5Z)-tetradec-2,5-enoyl-CoA→(3E,5Z)-tetradeca-3,5-dienoyl-CoA (EC 5.3.3.8)
No genes
Enoyl-CoA hydratase (in reverse):
(2E,5Z)-tetradec-2,5-enoyl-CoA + H2O→(S)-3-hydroxy-(5Z)-tetradecenoyl-CoA (EC 4.2.1.17)
Rv0130 +0.0
Rv0222 -0.2
Rv0456c -0.0
Rv0632c -0.2
Rv0673 +0.2
Rv0675 -0.6
Rv0860 N.D.
Rv0905 -0.5
Rv0971c -0.4
Rv1070c +0.2
Rv1071c -0.1
Rv1136 N.D.
Rv1141c +0.1
Rv1142c -0.2
Rv1472 -0.0
Rv1935c -0.6
Rv2486 +0.2
Rv2679 -0.3
Rv2831 +0.2
Rv3039c +0.0
Rv3373 N.D.
Rv3374 -0.6
Rv3516 +0.0
Rv3550 +0.3
Rv3774 +0.0
Long-chain-3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-(5Z)-tetradecenoyl-CoA + NAD+→3-oxo-(5Z)-tetradecenoyl-CoA + NADH + H+ (EC 1.1.1.211; 1.1.1.35)
Rv0468 -0.3
Rv0860 N.D.
Rv1144 +0.1
(3E,5Z)-tetradeca-3,5-dienoyl-CoA + H2O→(3E,5Z)-tetradeca-3,5-dienoate + coenzyme A + H+
No genes
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-(5Z)-tetradecenoyl-CoA + coenzyme A→acetyl-CoA + (3Z)-dodec-3-enoyl-CoA (EC 2.3.1.16)
Rv0243 -0.3
Rv0859 N.D.
Rv0914c +0.1
Rv1074c +0.1
Rv1135A N.D.
Rv1323 -0.3
Rv2790c +0.3
Rv3523 -0.0
Rv3546 -0.5
Rv3556c +0.1
Dodecenoyl-CoA isomerase:
(3Z)-dodec-3-enoyl-CoA→(2E)-dodec-2-enoyl-CoA (EC 5.3.3.8)
No genes
Long-chain-enoyl-CoA hydratase (in reverse):
(2E)-dodec-2-enoyl-CoA + H2O→(S)-3-hydroxydodecanoyl-CoA (EC 4.2.1.74)
No genes
Long-chain-3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxydodecanoyl-CoA + NAD+→3-oxododecanoyl-CoA + NADH + H+ (EC 1.1.1.211; 1.1.1.35)
Rv0468 -0.3
Rv0860 N.D.
Rv1144 +0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxododecanoyl-CoA + coenzyme A→acetyl-CoA + decanoyl-CoA (EC 2.3.1.16)
Rv0243 -0.3
Rv0859 N.D.
Rv0914c +0.1
Rv1074c +0.1
Rv1135A N.D.
Rv1323 -0.3
Rv2790c +0.3
Rv3523 -0.0
Rv3546 -0.5
Rv3556c +0.1
decanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-dec-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
Rv0244c N.D.
Rv0672 -0.1
Rv1467c +0.0
Long-chain-enoyl-CoA hydratase (in reverse):
(2E)-dec-2-enoyl-CoA + H2O→(S)-3-hydroxydecanoyl-CoA (EC 4.2.1.74)
Rv0222 -0.2
Rv0456c -0.0
Rv0632c -0.2
Rv0675 -0.6
Rv0905 -0.5
Rv1070c +0.2
Rv1136 N.D.
Rv1141c +0.1
Rv1142c -0.2
Rv1472 -0.0
Rv1935c -0.6
Rv2486 +0.2
Rv2679 -0.3
Rv2831 +0.2
Rv3039c +0.0
Rv3373 N.D.
Rv3374 -0.6
Rv3516 +0.0
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxydecanoyl-CoA + NAD+→3-oxodecanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Rv0468 -0.3
Rv0860 N.D.
Rv1144 +0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxodecanoyl-CoA + coenzyme A→acetyl-CoA + octanoyl-CoA (EC 2.3.1.16)
Rv0243 -0.3
Rv0859 N.D.
Rv0914c +0.1
Rv1074c +0.1
Rv1135A N.D.
Rv1323 -0.3
Rv2790c +0.3
Rv3523 -0.0
Rv3546 -0.5
Rv3556c +0.1
octanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-oct-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
Rv0244c N.D.
Rv0672 -0.1
Rv1467c +0.0
Long-chain-enoyl-CoA hydratase (in reverse):
(2E)-oct-2-enoyl-CoA + H2O→(3S)-3-hydroxyoctanoyl-CoA (EC 4.2.1.74)
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxyoctanoyl-CoA + NAD+→3-oxooctanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Rv0468 -0.3
Rv0860 N.D.
Rv1144 +0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxooctanoyl-CoA + coenzyme A→acetyl-CoA + hexanoyl-CoA (EC 2.3.1.16)
Rv0243 -0.3
Rv0859 N.D.
Rv0914c +0.1
Rv1074c +0.1
Rv1135A N.D.
Rv1323 -0.3
Rv2790c +0.3
Rv3523 -0.0
Rv3546 -0.5
Rv3556c +0.1
hexanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-hex-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
Rv0244c N.D.
Rv0672 -0.1
Rv1467c +0.0
Long-chain-enoyl-CoA hydratase (in reverse):
(2E)-hex-2-enoyl-CoA + H2O→(S)-3-hydroxyhexanoyl-CoA (EC 4.2.1.74)
Rv0222 -0.2
Rv0456c -0.0
Rv0632c -0.2
Rv0675 -0.6
Rv0905 -0.5
Rv1070c +0.2
Rv1136 N.D.
Rv1141c +0.1
Rv1142c -0.2
Rv1472 -0.0
Rv1935c -0.6
Rv2486 +0.2
Rv2679 -0.3
Rv2831 +0.2
Rv3039c +0.0
Rv3373 N.D.
Rv3374 -0.6
Rv3516 +0.0
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxyhexanoyl-CoA + NAD+→3-oxohexanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Rv0468 -0.3
Rv0860 N.D.
Rv1144 +0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxohexanoyl-CoA + coenzyme A→acetyl-CoA + butanoyl-CoA (EC 2.3.1.16; 2.3.1.9)
Rv0243 -0.3
Rv0859 N.D.
Rv0914c +0.1
Rv1074c +0.1
Rv1135A N.D.
Rv1323 -0.3
Rv1867 -0.1
Rv2790c +0.3
Rv3523 -0.0
Rv3546 -0.5
Rv3556c +0.1
butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→crotonyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
Rv3140 -1.2
Rv3504 +0.2
Rv3562 N.D.
Rv3573c -0.0
Rv3761c -0.0
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
Rv0222 -0.2
Rv0456c -0.0
Rv0632c -0.2
Rv0675 -0.6
Rv0905 -0.5
Rv1070c +0.2
Rv1136 N.D.
Rv1141c +0.1
Rv1142c -0.2
Rv1472 -0.0
Rv1935c -0.6
Rv2486 +0.2
Rv2679 -0.3
Rv2831 +0.2
Rv3039c +0.0
Rv3373 N.D.
Rv3374 -0.6
Rv3516 +0.0
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
Rv0468 -0.3
Rv0860 N.D.
Rv1144 +0.1
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
Rv0243 -0.3
Rv0859 N.D.
Rv0914c +0.1
Rv1074c +0.1
Rv1135A N.D.
Rv1323 -0.3
Rv1867 -0.1
Rv2790c +0.3
Rv3523 -0.0
Rv3546 -0.5
Rv3556c +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information