MetaCyc Pathway: valproate β-oxidation in Mycobacterium tuberculosis H37Rv

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Reactions and Genes Glycerol (C)
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Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
Rv0130 -0.2
Rv0222 -0.1
Rv0456c -0.2
Rv0632c -0.2
Rv0673 +0.2
Rv0675 -1.7
Rv0860 N.D.
Rv0905 -0.3
Rv0971c -0.3
Rv1070c -0.4
Rv1071c -0.3
Rv1136 N.D.
Rv1141c +0.1
Rv1142c -0.2
Rv1472 -0.1
Rv1935c +0.1
Rv2486 -0.1
Rv2679 -0.3
Rv2831 -0.3
Rv3039c -0.2
Rv3373 N.D.
Rv3374 +0.1
Rv3516 +0.1
Rv3550 +0.0
Rv3774 -0.3
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Rv0468 -0.1
Rv0860 N.D.
Rv1144 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
Rv0243 -1.6
Rv0859 N.D.
Rv0914c -0.2
Rv1074c +0.2
Rv1135A N.D.
Rv1323 -0.4
Rv2790c -0.1
Rv3523 +0.1
Rv3546 -0.2
Rv3556c +0.7
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
Rv3140 -1.0
Rv3504 +0.1
Rv3562 N.D.
Rv3573c +0.1
Rv3761c +0.2
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Rv0468 -0.1
Rv0860 N.D.
Rv1144 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
Rv0243 -1.6
Rv0859 N.D.
Rv0914c -0.2
Rv1074c +0.2
Rv1135A N.D.
Rv1323 -0.4
Rv1867 +0.2
Rv2790c -0.1
Rv3523 +0.1
Rv3546 -0.2
Rv3556c +0.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information