MetaCyc Pathway: (8E,10E)-dodeca-8,10-dienol biosynthesis in Mycobacterium tuberculosis H37Rv

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Reactions and Genes Glycerol (C)
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palmitoyl-CoA[in] + an oxidized electron-transfer flavoprotein[in] + H+[in]→(2E)-hexadec-2-enoyl-CoA[in] + a reduced electron-transfer flavoprotein[in] (EC 1.3.8.9)
No genes
(8E,10E)-dodeca-8,10-dienoate + 2 NADPH + 3 H+→(8E,10E)-dodeca-8,10-dienol + 2 NADP+ + H2O
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-hexadec-2-enoyl-CoA + H2O→(S)-3-hydroxyhexadecanoyl-CoA (EC 4.2.1.17)
Rv0130 -0.2
Rv0222 -0.1
Rv0456c -0.2
Rv0632c -0.2
Rv0673 +0.2
Rv0675 -1.7
Rv0860 N.D.
Rv0905 -0.3
Rv0971c -0.3
Rv1070c -0.4
Rv1071c -0.3
Rv1136 N.D.
Rv1141c +0.1
Rv1142c -0.2
Rv1472 -0.1
Rv1935c +0.1
Rv2486 -0.1
Rv2679 -0.3
Rv2831 -0.3
Rv3039c -0.2
Rv3373 N.D.
Rv3374 +0.1
Rv3516 +0.1
Rv3550 +0.0
Rv3774 -0.3
Long-chain-3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxyhexadecanoyl-CoA + NAD+→3-oxopalmitoyl-CoA + NADH + H+ (EC 1.1.1.211)
Rv0860 N.D.
Acetyl-CoA C-myristoyltransferase (in reverse):
3-oxopalmitoyl-CoA + coenzyme A→myristoyl-CoA + acetyl-CoA (EC 2.3.1.155)
Rv0859 N.D.
Rv0914c -0.2
Rv2790c -0.1
myristoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-tetradec-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-tetradec-2-enoyl-CoA + H2O→(S)-3-hydroxytetradecanoyl-CoA (EC 4.2.1.17)
Rv0130 -0.2
Rv0222 -0.1
Rv0456c -0.2
Rv0632c -0.2
Rv0673 +0.2
Rv0675 -1.7
Rv0860 N.D.
Rv0905 -0.3
Rv0971c -0.3
Rv1070c -0.4
Rv1071c -0.3
Rv1136 N.D.
Rv1141c +0.1
Rv1142c -0.2
Rv1472 -0.1
Rv1935c +0.1
Rv2486 -0.1
Rv2679 -0.3
Rv2831 -0.3
Rv3039c -0.2
Rv3373 N.D.
Rv3374 +0.1
Rv3516 +0.1
Rv3550 +0.0
Rv3774 -0.3
(S)-3-hydroxytetradecanoyl-CoA + NAD+→3-oxomyristoyl-CoA + NADH + H+
Rv0860 N.D.
Acetyl-CoA C-acyltransferase (in reverse):
3-oxomyristoyl-CoA + coenzyme A→lauroyl-CoA + acetyl-CoA (EC 2.3.1.16)
Rv0243 -1.6
Rv0859 N.D.
Rv0914c -0.2
Rv1074c +0.2
Rv1135A N.D.
Rv1323 -0.4
Rv2790c -0.1
Rv3523 +0.1
Rv3546 -0.2
Rv3556c +0.7
lauroyl-CoA + 2 a ferrocytochrome b5 + dioxygen + 2 H+→(9E)-dodecenoyl-CoA + 2 a ferricytochrome b5 + 2 H2O
No genes
(9E)-dodecenoyl-CoA + 2 a ferrocytochrome b5 + dioxygen + 2 H+→(8E,10E)-dodeca-8,10-dienoyl-CoA + 2 a ferricytochrome b5 + 2 H2O
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information