MetaCyc Pathway: superpathway of Clostridium acetobutylicum solventogenic fermentation in Mycobacterium tuberculosis H37Rv

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Reactions and Genes Glycerol (C)
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Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
Rv3535c +0.0
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
Rv0243 -1.6
Rv0859 N.D.
Rv0914c -0.2
Rv1074c +0.2
Rv1135A N.D.
Rv1323 -0.4
Rv1867 +0.2
Rv2790c -0.1
Rv3523 +0.1
Rv3546 -0.2
Rv3556c +0.7
Butyrate--acetoacetate CoA-transferase (in reverse):
acetoacetyl-CoA + butanoate→acetoacetate + butanoyl-CoA (EC 2.8.3.9)
No genes
Butyrate--acetoacetate CoA-transferase (in reverse):
acetoacetyl-CoA + acetate→acetoacetate + acetyl-CoA (EC 2.8.3.9)
No genes
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
Rv0162c +0.2
Rv0761c +0.1
Rv1530 -0.1
Rv1862 +0.0
Rv3045 +0.2
Rv3086 +0.1
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
Rv0468 -0.1
Rv0860 N.D.
Rv1144 -0.1
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
Rv0222 -0.1
Rv0456c -0.2
Rv0632c -0.2
Rv0675 -1.7
Rv0905 -0.3
Rv1070c -0.4
Rv1136 N.D.
Rv1141c +0.1
Rv1142c -0.2
Rv1472 -0.1
Rv1935c +0.1
Rv2486 -0.1
Rv2679 -0.3
Rv2831 -0.3
Rv3039c -0.2
Rv3373 N.D.
Rv3374 +0.1
Rv3516 +0.1
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
Rv3029c N.D.
Butanal dehydrogenase (in reverse):
butanoyl-CoA + NAD(P)H + H+→1-butanal + coenzyme A + NAD(P)+ (EC 1.2.1.57)
No genes
Alcohol dehydrogenase (NADP(+)) (in reverse):
1-butanal + NADPH + H+→butan-1-ol + NADP+ (EC 1.1.1.2)
No genes
1-butanal + NADH + H+→butan-1-ol + NAD+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information