MetaCyc Pathway: superpathway of coenzyme A biosynthesis II (plants) in Acidovorax sp. GW101-3H11

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Reactions and Genes D-Glucose (C)
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3-methyl-2-oxobutanoate hydroxymethyltransferase:
3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H2O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)
Ac3H11_3839 -3.0
Propionate--CoA ligase:
propanoate + ATP + coenzyme A→propanoyl-CoA + AMP + diphosphate (EC 6.2.1.17)
Ac3H11_2208 +0.3
Ac3H11_951 -2.2
2-dehydropantoate 2-reductase (in reverse):
2-dehydropantoate + NADPH + H+→(R)-pantoate + NADP+ (EC 1.1.1.169)
Ac3H11_2346 -0.2
Ac3H11_3373 N.D.
Ac3H11_3944 +0.1
Ac3H11_527 N.D.
propanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→acryloyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
Ac3H11_2359 +0.1
Ac3H11_2520 -0.1
acryloyl-CoA + H2O→3-hydroxypropanoyl-CoA (EC 4.2.1.116)
Ac3H11_4006 -0.3
3-hydroxyisobutyryl-CoA hydrolase:
3-hydroxypropanoyl-CoA + H2O→3-hydroxypropanoate + coenzyme A + H+ (EC 3.1.2.4)
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3-hydroxypropionate dehydrogenase:
3-hydroxypropanoate + NAD+→3-oxopropanoate + NADH + H+ (EC 1.1.1.59)
Ac3H11_3320 -0.1
Beta-alanine--pyruvate transaminase:
3-oxopropanoate + L-alanine→β-alanine + pyruvate (EC 2.6.1.18)
Ac3H11_4342 -0.1
Pantoate--beta-alanine ligase:
β-alanine + (R)-pantoate + ATP→(R)-pantothenate + AMP + diphosphate + H+ (EC 6.3.2.1)
Ac3H11_2786 -0.2
Ac3H11_3840 -0.3
Pantothenate kinase:
(R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H+ (EC 2.7.1.33)
Ac3H11_1875 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information