MetaCyc Pathway: L-tyrosine degradation I in Rhodanobacter denitrificans FW104-10B01

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Reactions and Genes R2A with Nickel (II) chloride 0.3125 mM
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Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
LRK54_RS00725 +1.2
LRK54_RS00830 +0.1
LRK54_RS01370 -0.3
LRK54_RS01600 -1.4
LRK54_RS10685 -0.5
LRK54_RS11155 +0.2
4-hydroxyphenylpyruvate dioxygenase:
3-(4-hydroxyphenyl)pyruvate + dioxygen→homogentisate + CO2 (EC 1.13.11.27)
LRK54_RS05850 -0.2
Homogentisate 1,2-dioxygenase:
homogentisate + dioxygen→4-maleyl-acetoacetate + H+ (EC 1.13.11.5)
LRK54_RS05845 +0.1
Maleylacetoacetate isomerase:
4-maleyl-acetoacetate→4-fumaryl-acetoacetate (EC 5.2.1.2)
LRK54_RS05735 -1.1
LRK54_RS15615 -0.2
Fumarylacetoacetase:
4-fumaryl-acetoacetate + H2O→acetoacetate + fumarate + H+ (EC 3.7.1.2)
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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information