MetaCyc Pathway: glycine betaine degradation I in Sinorhizobium meliloti 1021

Reactions and Genes	Paraquat dichloride 0.2 mg/ml
	remove
Betaine--homocysteine S-methyltransferase: glycine betaine + L-homocysteine→N,N-dimethylglycine + L-methionine (EC 2.1.1.5)
SMc04325	-0.0
Dimethylglycine oxidase: N,N-dimethylglycine + dioxygen + a tetrahydrofolate→sarcosine + hydrogen peroxide + a 5,10-methylenetetrahydrofolate (EC 1.5.3.10)
No genes
sarcosine + dioxygen + a tetrahydrofolate→glycine + hydrogen peroxide + a 5,10-methylenetetrahydrofolate (EC 1.5.3.24)
SMc02608	+0.1
SMc03932	+1.7
SMc03933	+2.0
Sarcosine oxidase: sarcosine + dioxygen + H₂O→glycine + formaldehyde + hydrogen peroxide (EC 1.5.3.1)
SMa1483	-0.1
SMc01987	+1.0
SMc02605	N.D.
SMc02606	-0.0
SMc02607	N.D.
SMc02608	+0.1
SMc03930	+2.4
SMc03931	+1.9
SMc03932	+1.7
SMc03933	+2.0
SMc04148	+0.1
Glycine hydroxymethyltransferase (in reverse): glycine + a 5,10-methylenetetrahydrofolate + H₂O→L-serine + a tetrahydrofolate (EC 2.1.2.1)
SMa2135	+0.0
SMc01770	+0.1
L-serine ammonia-lyase: L-serine→2-aminoprop-2-enoate + H₂O (EC 4.3.1.17)
SMc01256	+0.8
Tryptophanase: 2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
SMc01256	+0.8
2-iminopropanoate + H₂O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
SMc01256	+0.8

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Pathway details at MetaCyc
Fitness data for 15 genes
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All MetaCyc pathways for Sinorhizobium meliloti 1021

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information