MetaCyc Pathway: formaldehyde oxidation II (glutathione-dependent) in Sinorhizobium meliloti 1021

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Reactions and Genes Nickel (II) chloride 1 mM
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S-(hydroxymethyl)glutathione synthase (in reverse):
formaldehyde + glutathione→S-(hydroxymethyl)glutathione (spontaneous) (EC 4.4.1.22)
SM_b20186 -0.0
S-(hydroxymethyl)glutathione dehydrogenase:
S-(hydroxymethyl)glutathione + NAD(P)+→S-formylglutathione + NAD(P)H + H+ (EC 1.1.1.284)
SM_b20170 N.D.
SMa2113 +0.4
SMc01270 N.D.
S-formylglutathione hydrolase:
S-formylglutathione + H2O→formate + glutathione + H+ (EC 3.1.2.12)
SM_b20171 -0.2
SMc01273 +2.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information