MetaCyc Pathway: L-tyrosine degradation I in Sinorhizobium meliloti 1021

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Reactions and Genes NAG (C)
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Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
SM_b20039 -0.2
SMa0387 -0.1
SMc00294 -4.7
SMc00387 -0.1
SMc00490 -1.5
SMc00710 -0.7
SMc01406 +0.2
SMc01578 -3.7
SMc01969 -0.1
SMc02251 -0.1
SMc02262 +0.0
SMc02393 +0.1
SMc03885 -0.2
SMc04323 +0.4
SMc04326 -0.1
SMc04386 -0.4
4-hydroxyphenylpyruvate dioxygenase:
3-(4-hydroxyphenyl)pyruvate + dioxygen→homogentisate + CO2 (EC 1.13.11.27)
SM_b20581 -0.2
SMc03211 -0.0
Homogentisate 1,2-dioxygenase:
homogentisate + dioxygen→4-maleyl-acetoacetate + H+ (EC 1.13.11.5)
SMc03208 +0.1
Maleylacetoacetate isomerase:
4-maleyl-acetoacetate→4-fumaryl-acetoacetate (EC 5.2.1.2)
SMc03206 -0.2
Fumarylacetoacetase:
4-fumaryl-acetoacetate + H2O→acetoacetate + fumarate + H+ (EC 3.7.1.2)
SMc03207 -0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information