MetaCyc Pathway: 2-oxobutanoate degradation I in Sinorhizobium meliloti 1021

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Reactions and Genes L-Leucine (C)
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2-oxoisovalerate dehydrogenase (acylating):
2-oxobutanoate + coenzyme A + NAD+→propanoyl-CoA + CO2 + NADH (EC 1.2.1.25)
No genes
Propionyl-CoA carboxylase:
propanoyl-CoA + ATP + hydrogen carbonate→(S)-methylmalonyl-CoA + ADP + H+ + phosphate (EC 6.4.1.3)
SM_b20755 -0.4
SM_b20756 -0.8
SMc00690 N.D.
SMc02764 N.D.
Methylmalonyl-CoA epimerase (in reverse):
(S)-methylmalonyl-CoA→(R)-methylmalonyl-CoA (EC 5.1.99.1)
SMc01550 -0.0
SMc01930 -4.2
Methylmalonyl-CoA mutase:
(R)-methylmalonyl-CoA→succinyl-CoA (EC 5.4.99.2)
SM_b20757 -4.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information