MetaCyc Pathway: mevalonate degradation in Sinorhizobium meliloti 1021

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Reactions and Genes L-Leucine (C)
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Hydroxymethylglutaryl-CoA reductase:
(R)-mevalonate + coenzyme A + 2 NAD+→(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
(EC 1.1.1.88)
No genes
Hydroxymethylglutaryl-CoA lyase:
(S)-3-hydroxy-3-methylglutaryl-CoA→acetoacetate + acetyl-CoA
(EC 4.1.3.4)
SM_b21125 -6.8

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information