MetaCyc Pathway: L-tyrosine degradation V (reductive Stickland reaction) in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes L-Phenylalanine (C)
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Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
Pf6N2E2_1496 +0.4
Pf6N2E2_2127 +0.2
Pf6N2E2_2446 +0.0
Pf6N2E2_2519 +0.3
Pf6N2E2_2632 -2.8
Pf6N2E2_3173 -0.1
Pf6N2E2_3251 -3.9
Pf6N2E2_4288 -0.1
Pf6N2E2_4386 -0.1
Pf6N2E2_462 +0.1
Pf6N2E2_50 +0.3
Pf6N2E2_5300 -0.2
Pf6N2E2_5813 -0.0
Pf6N2E2_5890 -0.2
Pf6N2E2_5891 N.D.
Pf6N2E2_5895 -0.1
Pf6N2E2_5989 -0.3
Pf6N2E2_637 -0.0
Pf6N2E2_684 +0.1
Indolelactate dehydrogenase (in reverse):
3-(4-hydroxyphenyl)pyruvate + NADH + H+→(R)-3-(4-hydroxyphenyl)lactate + NAD+ (EC 1.1.1.110)
No genes
Cinnamoyl-CoA:phenyllactate CoA-transferase:
(R)-3-(4-hydroxyphenyl)lactate + (E)-4-coumaroyl-CoA→4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA (EC 2.8.3.17)
No genes
4-coumarate + a reduced electron-transfer flavoprotein→phloretate + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.15)
No genes
(R)-3-(4-hydroxyphenyl)lactoyl-CoA→(E)-4-coumaroyl-CoA + H2O (EC 4.2.1.175)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information