MetaCyc Pathway: superpathway of sulfate assimilation and cysteine biosynthesis in Sinorhizobium meliloti 1021

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Reactions and Genes L-Proline (C)
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Phosphoglycerate dehydrogenase:
3-phospho-D-glycerate + NAD+→3-phosphooxypyruvate + NADH + H+ (EC 1.1.1.95)
SM_b20113 -0.2
SMa0085 -0.1
SMa0510 -0.1
SMa1347 -0.1
SMa1838 +0.1
SMc00641 -4.8
SMc01622 -0.4
SMc02045 -0.3
SMc02332 +0.0
SMc02828 +0.1
SMc04462 +0.1
Sulfate adenylyltransferase:
sulfate + ATP + H+→adenosine 5'-phosphosulfate + diphosphate (EC 2.7.7.4)
SM_b21223 N.D.
SM_b21224 -0.0
SMa0855 N.D.
SMa0857 -0.1
SMc00090 -5.3
SMc00091 -4.0
Adenylyl-sulfate kinase:
adenosine 5'-phosphosulfate + ATP→3'-phosphoadenylyl-sulfate + ADP + H+ (EC 2.7.1.25)
SM_b21224 -0.0
SMa0857 -0.1
Phosphoserine transaminase (in reverse):
3-phosphooxypyruvate + L-glutamate→O-phospho-L-serine + 2-oxoglutarate (EC 2.6.1.52)
SMa1495 -0.0
SMc00640 -7.8
Phosphoadenylyl-sulfate reductase (thioredoxin) (in reverse):
3'-phosphoadenylyl-sulfate + a reduced thioredoxin→sulfite + adenosine 3',5'-bisphosphate + an oxidized thioredoxin + 2 H+ (EC 1.8.4.8)
SMc00092 -5.1
Phosphoserine phosphatase:
O-phospho-L-serine + H2O→L-serine + phosphate (EC 3.1.3.3)
SMc01494 -8.0
Serine O-acetyltransferase:
L-serine + acetyl-CoA→O-acetyl-L-serine + coenzyme A (EC 2.3.1.30)
SMc02113 N.D.
Sulfite reductase (NADPH) (in reverse):
sulfite + 3 NADPH + 5 H+→hydrogen sulfide + 3 NADP+ + 3 H2O (EC 1.8.1.2)
SMc02124 -5.8
Cysteine synthase:
O-acetyl-L-serine + hydrogen sulfide→L-cysteine + acetate + H+ (EC 2.5.1.47)
SMc00421 +0.1
SMc01174 -1.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information